Lectures 20-22: Auditory System Flashcards
Audible range in Hz and dB. What frequency are we most sensitive?
20 - 20,000 Hz (1,000 - 3,000 we are most sensitive) and 1 - 120 dB
External ear: parts and functions
Pinna (reflects low frequencies for vertical sound localization) and external auditory meatus (magnifies 3,000 Hz sound by passive resonance)
Middle ear: parts
Ossicles (malleus, incus, stapes), muscles (tensor tympani, stapedius), eustachian tube
Where does the stapes foot plate insert?
Oval window
Tensor tympani muscle innervation and function. What bone does it attach to?
Innervated by CNV, improves transmission of high frequencies; malleus
Stapedius muscle innervation and function
Innervated by CNVII, stiffens chain of ossicles to dampen sound (stapedius reflex)
Cochlea: parts, fluid, and function. Describe why one of the fluids is special.
Bony cochlea (filled with perilymph) and membranous cochlea (filled with viscous endolymph [high K+, low Na+])
Three cochlear compartments
Scala vestibuli (in), scala media (membranous), scala tympani (out)
How is sound transmitted?
Stapes oscillates, pressure wave transmitted through oval window –> scala vestibuli –> scala tympani (base to apex) –> round window
Where does hearing happen? Two membranes flanking scala media? Third membrane? Where are the hair cells?
Scala media; vestibular and basilar membrane; tectorial membrane; sit on basilar membrane and extend to tectorial membrane
Organ of Corti consists of…
Basilar membrane, inner and outer hair cells, tectorial membrane
Stria vascularis
Highly vascular structure that produces endolymph on lateral wall of Organ of Corti
Inner hair cells
Single row, responsible for hearing, 95% of input to auditory nerve
Outer hair cells
Three rows, critical for audition: input from superior olive, sharpen sound frequency resolution, protect hair cells from loud noise, otoacoustic emissions
Hair cells “hairs”
Sterocilia (arranged like staircase) and kinocilium (taller)
Deflection toward kinocilium
Depolarization of hair cell membrane –> exocytosis –> excites distal process of auditory nerve
Deflection away from kinocilium
Hyperpolarization of hair cell membrane –> less signal –> inhibits
Basilar membrane is wider and more flexible at the _______ for which kind of tones? And the converse? What is this called?
Apex = low tones; narrower and more rigid at base = high tones; tonotopic organization of basilar membrane
What is a special function of the outer hair cells? What are they vulnerable to?
Amplify movement of basilar membrane in response to low intensity sounds; vulnerable to aminoglycoside antibiotics (ototoxic)
Steps of hearing after hair cells
- Inner hair cells activate distal process of auditory nerve; 2. Cell bodies of auditory nerve fibers are located in Spiral Ganglion; 3. Proximal processes of auditory nerve enter brainstem and pontine-medullary junction
Projection pathway of auditory system
Cochlear nuclei (located lateral to inferior cerebellar peduncle) –> superior olive (some crossing here) –> inferior colliculus –> medial geniculate body (thalamus) –> auditory cortex
Superior olive is responsible for…how? Fibers from here ascend in what tract? What other fiber tract projects from here?
Horizontal localization of sound because it receives binaural input from cochlear nuclei; calculate interaural intensity (loudness) and timing differences; lateral lemniscus; also sends a projection back to outer hair cells via olivocochlear bundle
Input from olivocochlear bundle does what? (2)
Selective auditory attention when there is background noise, protection from loud noise
Where do we find the medial geniculate nuclei?
Hanging off the thalamus at the level of the midbrain
Were does the medial geniculate nucleus project?
NOT through internal capsule, but sneak behind posterior limb of IC through the auditory radiation and synapse at Heschl’s gyri
Describe Heschl’s gyri tonotopic organization
Anterior –> low, Posterior –> high frequency (corresponding apex –> base)
What else does the auditory cortex convey?
What and where sound information
Newborn hearing test looks for (2)
Otoacoustic emissions (haircell dance) and auditory brainstem responses
What two important pieces of information are conveyed by the peripheral vestibular system?
- Angular acceleration of the head; 2. Linear acceleration of the head (up and down)
Vestibulo-thalamo-cortical pathway does what? What thalamic nucleus? To where in cortex?
Conscious perception of equilibrium; VP nucleus (contralateral); posterior parietal cortex (primary vestibular cortex)
Vestibulo-ocular reflex (VOR). Afferent and efferent limb?
Steady gaze during head movement; afferent limb = vestibular, efferent limb = oculomotor