Lecture 2: Histology Flashcards

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1
Q

Atypical synapse in which synapse is along the axon

A

En passant synapse

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2
Q

What does the neuromuscular junction contain?

A

Enlarged terminal with synaptic vesicles, enlarged cleft, and the muscle sole plate

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3
Q

Where do we find multipolar neurons?

A

Throughout the CNS

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4
Q

Where do we find bipolar neurons?

A

In the “special sensory” regions

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5
Q

Where do we find unipolar neurons?

A

In the sensory ganglia (DRG)

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6
Q

Star-shaped granule cells are called?

A

Stellate cells

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7
Q

Granule/stellate cells regulate

A

Regional information processing

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8
Q

What are three ways to classify a neuron based on its axon length?

A

Projection cells, interneurons, amacrine cells

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9
Q

T/F: Interneurons are generally excitatory

A

False. Interneurons remain within the region of a dendritic field and provide local synpatic interactions and feedback.

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10
Q

What are amacarine cells? Where are they primarily found?

A

Axon-less cells; retina and olfactory bulb

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11
Q

Three types of neuronal cell death

A

Necrosis, apoptosis, autophagy

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12
Q

What is different about microglial cell origins?

A

Derived from mesoderm, not ectoderm like astrocytes and oligodendrocytes

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13
Q

Broadly, microglia are the…

A

Resident macrophages of the CNS

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14
Q

Microglia can exist in resting states and active states. What are the two active states?

A

Non-phagocytic microglia (immediately responsive) and phagocytic microglia (apoptose neurons during development and respond to trauma)

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15
Q

What are the five main functions of astrocytes?

A

Structural/metabolic support, scaffolding during development, regulate ions/extracellular molecules, blood-brain barrier, CNS scars

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16
Q

Astrocytomas make up __% of primary brain tumors. What is the most common? Describe.

A

50%; Glioblastoma multiforme: fast-growing tumor cells surrounding necrotic region called pseudopalisading necrosis

17
Q

What are the two histological characteristics of oligodendrogliomas?

A

“Fried egg” cells and “chicken wire” capillaries

18
Q

What are tumors of ependymal cells called?

A

Ependymomas

19
Q

What characterizes ependymomas?

A

Pseudorosettes

20
Q

What are tumors of Schwann cells called? Describe.

A

Schwannomas; typically encapsulated and benign