Lecture mon sept 23 (L4) Flashcards
how significant is example: the valine vs. leucine mutation?
Not very significant because both are non-polar
What keeps the alpha helix amino acid held together?
Hydrogen bonding
What is an amino acid residue?
An amino acid bonded to 2 or more other amino acids (because no longer has same chem structure as before)
In a polypeptide chain, how to know which amino acid it’ll hydrogen bond with
add 4, ex: a.a residue #5 is connected to a.a residue #9
How many amino acid resiudes per turn?
3.6
Length of 1 turn in an alpha helix?
0.34nm
How is the hydrogen bonding formed between?
Hydrogen attached to nitrogen and carboxyl group
What holds beta sheets together?
Hydrogen bonding
Different configurations of β sheet
Antiparallel – backbone run in opposite direction
* Parallel – backbone run in same direction
* Mixed - combination of parallel and antiparallel
What is a single domain protein?
A group of beta sheets, or aplha helix sheets (can also be a mix of both)
What is teritary level?
When the protein consists of multiple domains
(ex: domain 1 has all alpha,dom 2 has all beta, dom 3 has a mix of both)
What is the quatenary level of proteins?
Multiple protein associates together to form a larger, more complex structure
What is domain shuffling?
Cutting and recombining different domains to give proteins new functions
What type of molecule is hemoglobin?
Heterotetramer
