LECTURE 9: PK AND PD Flashcards
1
Q
The loading dose:
A
The amount of drug given initially to obtain the desired plasma concentration as soon as possible, a loading dose is usually expressed in mg/kg
2
Q
The maintenance dose rate:
A
The rate at which drug needs to be administered to maintain the desired plasma concentration, a maintenance dose rate is usually expressed in mg/kg/min
3
Q
Loading Dose and Maintenance Dose Rate are both related to desired
A
plasma concentration and bioavailability
4
Q
to work out dose interval we need to know
A
- elimination half-life
- therapeutic window
- compliance
5
Q
the time it takes for the plasma concentration to halve on account of the drug being eliminated from the body
Depends on two things:
A
- clearance
- vod
6
Q
Loading dose uniquely related to
A
volume of distribution
7
Q
Maintenance dose rate uniquely related to
A
drug clearance
