LECTURE 22: ANTIBACTERIAL Flashcards
1
Q
Antimicrobial resitence
A
when microbe stops responding to a drug
2
Q
what leads to resistence
A
- incorrect prescription
- not finishing prescription
- using broad spectrum antibiotics
3
Q
bacteria develop resistence in a number of ways:
A
- mutations
- horizontal gene transfer
- modifying the target site
- inactivating drug with enzyme
- increase efflux pumps or decrease membrane permeability
4
Q
antibitoics major targets
A
- inhibit cell wall synthesis
- inhibit protein synthesis
- inhibit DNA synthesis
- inhibit folic acid synthesis
5
Q
bacteriostatic
A
stop reproduction
6
Q
bactericidal
A
kill
7
Q
beta lactam e.g.
A
penicillin
8
Q
beta lactam resistence by what enzyme
A
beta lactamase
9
Q
how to overcome beta lactamase problem
A
admisiter beta lactamase inhibitor
10
Q
beta lactam moa
A
bind to PBP - blocking final step of cell wall synthesis
11
Q
penicillin is a bacter…
A
bactericidal
12
Q
eg bacteriostatic
A
tetracycline
13
Q
fluoroquinolone
A
inhibits DNA gyrase -> broken DNA strands -> death
14
Q
eg fluoroquinolone
A
ciprofloxacin
15
Q
tetracycline eg
A
tetracycline and doxocycline
16
Q
tetracycline
A
inhibits protein syntheis by bind to 30S, blocking translation
