LECTURE 22: ANTIBACTERIAL Flashcards
Antimicrobial resitence
when microbe stops responding to a drug
what leads to resistence
- incorrect prescription
- not finishing prescription
- using broad spectrum antibiotics
bacteria develop resistence in a number of ways:
- mutations
- horizontal gene transfer
- modifying the target site
- inactivating drug with enzyme
- increase efflux pumps or decrease membrane permeability
antibitoics major targets
- inhibit cell wall synthesis
- inhibit protein synthesis
- inhibit DNA synthesis
- inhibit folic acid synthesis
bacteriostatic
stop reproduction
bactericidal
kill
beta lactam e.g.
penicillin
beta lactam resistence by what enzyme
beta lactamase
how to overcome beta lactamase problem
admisiter beta lactamase inhibitor
beta lactam moa
bind to PBP - blocking final step of cell wall synthesis
penicillin is a bacter…
bactericidal
eg bacteriostatic
tetracycline
fluoroquinolone
inhibits DNA gyrase -> broken DNA strands -> death
eg fluoroquinolone
ciprofloxacin
tetracycline eg
tetracycline and doxocycline
tetracycline
inhibits protein syntheis by bind to 30S, blocking translation