Lecture 8.1

Question 1

What comprises of the Lamina terminalis?

Answer 1

OVLT and SFO

Question 2

What does the OVLT do?

Answer 2

Regulates osmolality by measuring volume and through cell stretch

Question 3

Name the 2 places osmolality is detected

Answer 3

Peripheral receptors and central receptors (OVLT, SON and PVN)

Question 4

What is the pathway from the Lamina terminalis to the posterior pituitary?

Answer 4

OVLT-Hypothalams (SON and PVN)- Posterior Pituitary

Question 5

What gets secreted from the posterior pituitary?

Answer 5

Oxytocin and Vasopressin

Question 6

Describe the hormone Oxytoxin and what it does

Answer 6

It is a hormone, begins the cycle of labor, released when the cervix stretches, and when the nipples are stimulated when breastfeeding

Question 7

Describe the hormone Vasopressin (AVP) and what it does

Answer 7

It is a hormone that increases the re-uptake of water into the blood

Question 8

Describe the molecular process when Vasopressin is released

Answer 8

AVP attaches to a V2 G coupled receptors, activates GalphaS and adenylate cyclase, this stimulates production of cAMP, which increases PKA and protein phosphorylation. This is turn increases production of Aquaporins which increase the amount of water moving into the lumen and increasing the concentration of urine

Question 9

What inhibits the normal function of Vasopressin?

Answer 9

Alcohol

Question 10

What are TRP receptors?

Answer 10

Ion channels on plasma membrane that sense osmotic pressure, volume and stretch