Lecture 10.1 Flashcards

1
Q

Name 5 psychiatric diseases

A

Schizophrenia, Depression, Autism, Bipolar disorder, Parkinson’s

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2
Q

What are 2 things that effect whether someone has a psychiatric disease?

A

Genetics and environment

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3
Q

How do we study genetics, environment and disease? 2 possibilities and describe

A

Genome wide association studies (GWAS)- large group of people, can miss rare mutations
Sequencing of parents, affected patients and unaffected siblings- can identify number of variations such as deletions and can isolate the mutation

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4
Q

Where are the main mutations in the synapse?

A

Neurexins 1, Neuroligin 1/2/4, Shank 2/3

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5
Q

Why is Neuroligin 3 so important in Autism?

A

As Neuroligin 2 with 2 mutations produce Autism( gene deletion and point mutation- cysteine is substitutes for arginine on position 451)

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6
Q

What is construct validity of NL3R451C model for humans in mice?

A

The physical changing of the mouse gene with the human gene with replacement

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7
Q

What is the face validity of NL3R451C?

A

Behavioural changes that occur in the mice such as aggression (what we see in humans with Autism)

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8
Q

What is the predictive validity in NL3R451C?

A

Aggression can be stopped with a drug that is used to treat aggression in Autistic humans

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9
Q

Finish the sentence: Mutation in proteins within the synapse lead to…

A

Autism influenced Gi dysfunction independent of behavioural changes

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