Lecture 10.1 Flashcards
Name 5 psychiatric diseases
Schizophrenia, Depression, Autism, Bipolar disorder, Parkinson’s
What are 2 things that effect whether someone has a psychiatric disease?
Genetics and environment
How do we study genetics, environment and disease? 2 possibilities and describe
Genome wide association studies (GWAS)- large group of people, can miss rare mutations
Sequencing of parents, affected patients and unaffected siblings- can identify number of variations such as deletions and can isolate the mutation
Where are the main mutations in the synapse?
Neurexins 1, Neuroligin 1/2/4, Shank 2/3
Why is Neuroligin 3 so important in Autism?
As Neuroligin 2 with 2 mutations produce Autism( gene deletion and point mutation- cysteine is substitutes for arginine on position 451)
What is construct validity of NL3R451C model for humans in mice?
The physical changing of the mouse gene with the human gene with replacement
What is the face validity of NL3R451C?
Behavioural changes that occur in the mice such as aggression (what we see in humans with Autism)
What is the predictive validity in NL3R451C?
Aggression can be stopped with a drug that is used to treat aggression in Autistic humans
Finish the sentence: Mutation in proteins within the synapse lead to…
Autism influenced Gi dysfunction independent of behavioural changes