Lecture 10.1

Question 1

Name 5 psychiatric diseases

Answer 1

Schizophrenia, Depression, Autism, Bipolar disorder, Parkinson’s

Question 2

What are 2 things that effect whether someone has a psychiatric disease?

Answer 2

Genetics and environment

Question 3

How do we study genetics, environment and disease? 2 possibilities and describe

Answer 3

Genome wide association studies (GWAS)- large group of people, can miss rare mutations
Sequencing of parents, affected patients and unaffected siblings- can identify number of variations such as deletions and can isolate the mutation

Question 4

Where are the main mutations in the synapse?

Answer 4

Neurexins 1, Neuroligin 1/2/4, Shank 2/3

Question 5

Why is Neuroligin 3 so important in Autism?

Answer 5

As Neuroligin 2 with 2 mutations produce Autism( gene deletion and point mutation- cysteine is substitutes for arginine on position 451)

Question 6

What is construct validity of NL3R451C model for humans in mice?

Answer 6

The physical changing of the mouse gene with the human gene with replacement

Question 7

What is the face validity of NL3R451C?

Answer 7

Behavioural changes that occur in the mice such as aggression (what we see in humans with Autism)

Question 8

What is the predictive validity in NL3R451C?

Answer 8

Aggression can be stopped with a drug that is used to treat aggression in Autistic humans

Question 9

Finish the sentence: Mutation in proteins within the synapse lead to…

Answer 9

Autism influenced Gi dysfunction independent of behavioural changes