Lecture 8- pulp (travers)

Question 1

… binds to collagen in forming dentin matrix and attracts Calcium ions to initiate mineralization

Answer 1

Dentin Phosphoprotein

Question 2

2 molecules secreted from enamel know of enamel organ that induce odontoblast differentiation

Answer 2

BMP

Wnt10A

Question 3

…. expression immediately precedes the “wave” of odontoblast differentiation

Answer 3

Wnt10A

Question 4

… signaling is also important in the adult pulp. … is released by pulp cells after injury

Answer 4

Wnt

Question 5

Modifying the Wnt receptor complex to amplify effect of Wnt binding increases production of…. and…. in animal models

Answer 5

reparative dentin

dentin proteins

Question 6

in dentin there is mostly only collagen type…. but in the pulp there is collagen type …. and…

Answer 6

1

1&3

Question 7

Does mature pulp contain DSPP?

Answer 7

no

Question 8

Dentin phosphoprotein is made by…. and is a product of…

Answer 8

odontoblast

DSPP gene

Question 9

Dentin phosphoprotein is highly…. and high in…

Answer 9

phosphorylated

serine/ aspartic acid

Question 10

is dentin phosphoprotein neg or pos charged?

What is dentin phosphoprotein relatively specific to?

Answer 10

negatively

dentin

Question 11

dentinogenesis begins during… stage when the crown outline is present but there are no ameloblasts or odontoblasts

Answer 11

bell

Question 12

In the late bell stage, IEE form…. and undifferentiated mesenchymal cells (dental papilla) form…. and both … and… are secreted

Answer 12

ameloblasts
odontoblasts
dentin and enamel

Question 13

dentinogenesis occurs from … to…. and from…. to….

Answer 13

cusp tips to cervix

periphery to pulp center

Question 14

resident immune cells of the pulp

Answer 14

macrophages
lymphocytes
eosinophils
dendritic cells

Question 15

cells present in pulp during inflammation

Answer 15

palsma cells
mast cells
pmns

Question 16

other cells besides immune cells of the pulp

Answer 16

odontoblasts
fibroblasts
stem cells

Question 17

The extracellular matrix of pulp is secreted by…

Answer 17

fibroblasts

Question 18

the smaller pg’s and associates (GAGs)

Answer 18

decorin, byglycan

Question 19

the larger pg’s and associates (GAGs)

Answer 19

versican, syndecan

Question 20

GAGs

Answer 20

dermatan, chondroitin, heparin sulfate

Question 21

functions of pg’s and gags

Answer 21

matrix for diffusion
collagen fibrillogenesis
water retention (pressurizes pulp to resist forces)

Question 22

role of glycoproteins (fibronectin) inECM of pulp

Answer 22

cell adhesion

Question 23

function of collagen type 1 and 3 in pulp

Answer 23

tensile strength

Question 24

… can transform into new odontoblasts after injury

Answer 24

pericytes

Question 25

… named for its function in transforming leukocyte precursors into granulocytes (neutrophils)

Answer 25

G-CSF

Question 26

functions of G-CSF

Answer 26

• chemotactic for many types of stem cells including DPSCs
• promotes neurogenesis and angiogenesis
• anti-apoptotic

Question 27

What between odontoblasts maintain position and polarity?

Answer 27

desmosomes and adherens

Question 28

what is between odontoblasts to maintain channels to coordinate dentinogenesis

Answer 28

gap junctions