Lecture 3- Odontogenesis- molecular and cellular Flashcards
osteogenesis imperfecta is a mutation in
COL1A1 (type 1 collagen)
autosomal dominant means you only need
1 mutant allele to cause phenotype
autosomal recessive needs …
2 mutant alleles to change phenotype
amelogenesis imperfecta is mutations in
AMELX gene on X chromosome
if father has amelogenesis imperfecta, only the … are affected
daughters
if the mother has amelogenesis imperfecta…. who is affected?
son or daughter can be
induction is the process that
initiates differentiation
an inducer is an agent that provides cells with a signal to differentiate BUT a cell must
be competent to receive the signal
… is the ability of cell to receive and respond to a molecular signal
competence (through receptors or internal machinery)
Bone morphongenetic protein (BMP) is an inducer and its receptor is…
cell surface BMP receptor type 1 or 2
Vitamin D is the inducer what is the receptor?
intracellular vitamin D receptor (VDR)
Wnt signal is the inducer, what is the receptor?
cell surface LRP6 and frizzled receptor
signaling affects….
- cell differentiation
- cell proliferation
- cell migration
3 types of signaling
autocrine
paracrine
endocrine
… control gene expression
transcription
transcription factors are proteins that control whether genes will be transcribed into…
mRNA
One TF can control expression of…. of genes
dozens, hundreds
TFs can … or… expression of target genes
activate of repress
DLX3 stands for
distal-less homeobox 3
mutations in DLX3 lead to…
tricho-dento-osseous syndrome
DLX3 regulates…
- hair follicle differentiation (BMP signaling)
- enamel genes (amelogenin, enamelin, kallikrein 4)
- bone (formation, resorption, homeostasis)
The hindbrain forms 8…. and they define the origins of distinct populations of NCCs
rhombomeres
NCCs from midbrain and rhombomeres 1 and 3 contribute to…
branchial arch 1
NCCs from rhombomeres 3 and greater express…. TFs
Hox TFs
