Lecture 7- AI genetics (bartlett)

Question 1

enamel formation starts at…. and proceeds…

Answer 1

cusp tip

cervically

Question 2

… cleaves enamel matrix prteins during early enamel development

Answer 2

MMP-20

Question 3

… first grow in length and later grow in width and thickness

Answer 3

hydroxyapatite crystallites

Question 4

… cleaves enamel matrix proteins during late enamel development so that the proteins can be removed from the matrix

Answer 4

KLK4

Question 5

the secretory stage involves structural enamel proteins…

Answer 5

amelogenin
ameloblastin
enamelin

Question 6

the secretory stage involves the enamel proteinase….

Answer 6

matrix metalloproteinase-20

Question 7

the maturation stage involves the enamel proteinase…

Answer 7

kallikrein 4

Question 8

hypoplastic amelogenesis imperfecta is caused from defects in the … stage

Answer 8

secretory

Question 9

hypomaturation amelogenesis imperfecta is caused from defectss in the… stage

Answer 9

maturation

Question 10

hypocalcified amelogenesis imperfecta is caused from defects in what stage?

Answer 10

both secretory and maturation

Question 11

3 types of amelogenesis imperfecta

Answer 11

hypoplastic
hypomaturation
hypocalcified

Question 12

… is an enamelysin, is involved in the secretory stage and processes enamel proteins

Answer 12

MMP20

Question 13

…. is a serine proteinase, is involved in the maturation stage and degrades enamel matrix

Answer 13

Kallikrein 4

Question 14

Ameloblastin ….. deletion causes AI

Answer 14

Exon 6

Question 15

a defect in Enamelin will cause autosomal…. hypoplastic AI

Answer 15

dominant

Question 16

a defect in ameloblastin will cause autosomal … hypoplastic AI

Answer 16

recessive

Question 17

AI from amelogenin defect causes …. hypoplastic AI

Answer 17

x-linked (son cannot get from father)