Lecture 8 - Genetics of ageing

Question 1

what are the two unifying themes for ageing across species?

Answer 1

insulin signalling, mTOR and rapamycin

Question 2

what are the 2 progeria syndromes?

Answer 2

werner and hutchinson-gilford

Question 3

name some of the features associates with progeria syndromes like werner syndrome

Answer 3

short stature, cataracts, early greying, osteoporosis, type 1 diabetes, atherosclerosis and early death

Question 4

what is the DNA helicase protein associated with werner syndrome causing telomere defects?

Answer 4

WRN

Question 5

what is the protein associated with hutchinson-gilford syndrome which affects laminin ageing?

Answer 5

LMNA

Question 6

name 2 other progeria syndromes apart from werner or hutchinson-gilford which involve DNA repair

Answer 6

cockayne syndrome and tricothiodystrophy

Question 7

name two gene polymorphisms associated with the downregulation of the insulin pathway and therefore longer life

Answer 7

IGF1R and FOXO3A