Lecture 4 - Future of Ageing

Question 1

what is the biggest risk factor for chronic disease?

Answer 1

old age

Question 2

name 4 interventions for anti-ageing

Answer 2

caloric restriction
med diet
exercise
drugs
cellular reprogramming
transfer of blood/plasma from young to old
targeted deletion of very aged cells (senolysis)

Question 3

name 3 drugs used for interventions with anti-ageing

Answer 3

metformin, rapamycin and resvetarol

Question 4

name the 5 primary hallmarks of ageing

Answer 4

genomic instability
telomere attrition
epigenetic alteration
loss of proteostasis
disabled macroautophagy

Question 5

name the 3 antagonistic hallmarks of ageing

Answer 5

cellular senescence
mitochondrial dysfunction
deregulated nutrient sensing

Question 6

name the 4 integrative hallmarks of ageing

Answer 6

dysbiosis
chronic inflammation
altered intercellular communication
stem cell exhaustion

Question 7

what does rapamycin inhibit?

Answer 7

mTOR

Question 8

which property of model organisms, not reproduced in humans, makes them good for studying the entire ageing process?

why do they need this property?

Answer 8

higher plasticity - greater need to adapt their biology to short term changes in food and environment