Lecture 27 - Biomarkers of ageing Flashcards
what is the biomarker used for dementia?
mild cognitive impairment (MCI)
name the 3 molecular imaging techniques used to visualise biomarkers for dementia
PET, fMRI, SPECT
name the 4 types of damage/changes which can be visualised using structural imaging (MRI)
vascular damage, white matter signal changes, spongiform and gliotic changes
what can PET and SPECT scanning visualise and quantify patterns of in the brain?
brain hypometabolism and hypoperfusion
which functional imaging technique is used to determine cental dopaminergic depletion in diseases like parkinson’s and lewy body dementia?
dopamine transporter scanning
name the 4 radiotracers used to visualise AB plaques in alzheimer’s in molecular brain imaging
PIB, 18F flutemetamol, 18F-AV-45, Florbetaben
in living patients, alpha-synuclein deposits in parkinson’s occur in which 5 body locations?
minor salivary glands, submandibular gland, stomach, colon, skin
give some examples of locations in the body where alpha-synuclein deposits can be found postmortem
stellate ganglion, vagus nerve, epicardial plexus, enteric nervous system, adrenal gland, genitourinary tract
what are the traditional biomarkers in the blood and CSF for alzheimer’s?
p-tau increased, AB42 decreased
If the diagnosis is uncertain and dementia
with Lewy bodies is suspected which type of SPECT should be used? Which technique should be used if this one is unavailable?
123 I-FP-CIT SPECT, 123 I-MIBG cardiac scintigraphy
which oligodendrocytic protein is elevated in prion diseases and mild AD?
S1000B