Lecture 8: Case 3 Flashcards
Identify round cell tumors 1-5
- Lymphoma
- TVT
- MCT
- PCT
- Histiocytic a
what is the most common hematopoietic tumor in animals
lymphoma
lymphoma has what paraneoplastic syndrome
hypercalcemia
lymphoma is characterized based on
- Size
- B, T or NK cell
- Flow cytometry
what is N:C ratio for lymphoma
high
what are cytoplasmic features for lymphoma
small amount, vary hues if blue (basophilic)
if there is not cytological confirmation of lymphoma what do you do next
PCR for antigen receptor rearrangement
if there is cytological confirmation of lymphoma what do you do next
flow cytometry, IHC
who does TVT occur in
free-roaming, sexually actives animals living in temperate climates
how are neoplastic TVT cells transplanted
between MM- oral cavity, nasal cavity, genitalia
what is N:C ratio for TVT
moderate
what are some cytoplasmic features for TVT
distinct/punctate vacoules, pale basophilic cytoplasm
what tumor
TVT
what dogs breeds are predisposed to MCT
boxers, pugs, Boston terriers
what paraneoplastic syndromes associated with MCT
- Gastric ulcers
- Localized inflammation
- Anaphylactic shock
what cats are predisposed to MCT
young Siamese and Burmese
what is mastocytemia
mast cells present in circulation
mastocytemia is always a __finding secondary to __
abnormal, secondary to inflammatory disease of neoplasia
what is N:C ratio for MCT
moderate
what are cytoplasmic features for MCT
purple granules, moderate amount of pale
what tumor
MCT
what is grade I MCT
well differentiated, granulated mast cells- better prognosis
what is grade III MCT
high change of local reoccurrence and metastasis to regional LN
what additional diagnostics do you do for MCT
- Grade
- FNA draining LN
- Evaluate +/- FNA liver and spleen
what type of tumor
PCT
what is N:C ratio for plasma cells
moderate
what are cytoplasmic features for plasma cells
perinuclear clear zone, moderate amount of deeply basophilic cytoplasm
what are some paraneoplastic syndromes for multiple myeloma
- Hypercalcemia- PTHrp or osteoblasts
- Hyper viscosity syndrome
need 2 of the following 4 to dx multiple myeloma
- Rad evidence of osteolysis
- > 20% of plasma cells in bone marrow
- Monoclonal gammopathy on SPE
- Proteinuria
canine histiocytoma more common in who
young dogs <3yrs
histiocytomas originate where
langerhans cells in the epidermis of skin
young dog what tumor
Histiocytoma
what is N:C ratio for histiocytoma
moderate
what are some cytoplasmic features for histiocytoma
moderate amount of pale basophilic cytoplasm
what type of tumor
histiocyțoma
plasma cell vs histiocytoma has what
PCT: more ansiocytosis, more ansiokaryosis, binucleation, multinucleation
