lecture 8

Question 1

hypersensitivity diseases- inflammation and tissue damage are caused by

Answer 1

autoimmune or excessive/uncontrolled immune responses

Question 2

type 1 hypersensitivity

Answer 2

called anergy, atopy or immediate hypersensitivity

Question 3

type 1 hypersensitivity is caused by

Answer 3

IgE antibodies and activation of mast cells

Question 4

initiation of type 1 hypersensitivity

Answer 4

Allergen-induced activation of the Th2 cells

Question 5

predisposition to atopic diseases

Answer 5

environmental factors (hygiene), genetic factors and nature of the allergens

Question 6

type 2 hypersensitivity is caused by

Answer 6

tissue-bound IgG and IgM antibodies specific for cellular and tissue antigens

Question 7

type 3 hs. is caused by

Answer 7

circulating immune complexes formed by IgG and IgM antibodies

Question 8

mechanism of type 2 and 3 hyperse.

Answer 8

activation of phagocytosis; the complement system, recruitment of inflammatory cells, blocking cell functions

Question 9

type 4 hs. caused by

Answer 9

cytotoxic T lymphocytes that directly kill target cells or Th cells that induce inflammation

Question 10

new therapeutic approaches for atopic diseases are

Answer 10

desensibilization, induction of Th1 responses and IgG production

Question 11

approaches for treatment of autoimmune responses

Answer 11

anti-inflammatory drugs and anti-cytokine therapy