lecture 3 Flashcards
What recognize T cells?
- peptides on antigen-presenting cells (APC)
What is MHC?
- cluster of highly polymorphic genes divided into MHC class I and class II gene loci
What display MHC class I and II?
antigens (peptides) to T cells
Human MHC is…
HLA human leukocyte antigen
MHC I molecules are composed of
alpha chain and non-polymorphic ß2-microglobulin
what is the function of MHC I molecules?
- presentation of cytoplasmic and intracellular antigens
In which groups are MHC I molecules divided?
a,b,c
MHC II molecules are composed of?
2 polymorphic protein chains
- 1 alpha chain and one ß chain
name the function of MHC II molecules
presentation of endosomol extracellular antigens
MHC II molecules are divided into
group d,q,b
To which type of T cells display MHC I molecules peptides?
CD8+ T cells
Which MHC molecules display peptides to CD4+ T cells?
MHC II molecules
What is the major barrier in tissue transplantation?
MHC
What happens usually after transplantation to genetically non-identical individuals?
graft rejection
Name the types of transplantation
- syngeneic
- allogeneic
- xenogeneic