Lecture 6 Flashcards
BCR recognize which kind of native molecules?
peptides, proteins, small chemicals etc.
location of naive B cells
in follicles of peripheral lymphoid organs
how are B cells activated?
antigen recognition, clonal expansion and differentiation into plasma cells, generation of memory B cells
What is secreted by plasma cells?
antibodies
What induces T cell dependent B cell response?
protein antigens
How does the T cell dependent B cell response work?
B cell presents antigens to Th cell and receives activating signals from the T cell
what is activated during primary and secondary immune response?
memory b cells
what are germinal centers?
place of B cell affinity maturation and isotope switching
explain affinity maturation
somatic mutations of immunoglobulin genes and selection of high-affinity B cells by follicular dendritic cells (FDC)
What induces immunoglobulin isotope switching?
induced by antigen-activated B cells that receive signals from helper T cells (CD40L, cytokines)
What define antibody isotopes (classes)
their effector function
list effector functions of antibodies
- neutralization
- phagocyte activation
- antibody-dependent cellular cytotoxicity
- antibody-mediated helminth killing
- complement activation by classical pathway, mucosal immunity (IgA)
how are antibodies recognized?
by Fc receptors on different cells