Lecture 6 Flashcards

1
Q

BCR recognize which kind of native molecules?

A

peptides, proteins, small chemicals etc.

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2
Q

location of naive B cells

A

in follicles of peripheral lymphoid organs

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3
Q

how are B cells activated?

A

antigen recognition, clonal expansion and differentiation into plasma cells, generation of memory B cells

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4
Q

What is secreted by plasma cells?

A

antibodies

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5
Q

What induces T cell dependent B cell response?

A

protein antigens

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6
Q

How does the T cell dependent B cell response work?

A

B cell presents antigens to Th cell and receives activating signals from the T cell

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7
Q

what is activated during primary and secondary immune response?

A

memory b cells

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8
Q

what are germinal centers?

A

place of B cell affinity maturation and isotope switching

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9
Q

explain affinity maturation

A

somatic mutations of immunoglobulin genes and selection of high-affinity B cells by follicular dendritic cells (FDC)

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10
Q

What induces immunoglobulin isotope switching?

A

induced by antigen-activated B cells that receive signals from helper T cells (CD40L, cytokines)

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11
Q

What define antibody isotopes (classes)

A

their effector function

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12
Q

list effector functions of antibodies

A
  1. neutralization
  2. phagocyte activation
  3. antibody-dependent cellular cytotoxicity
  4. antibody-mediated helminth killing
  5. complement activation by classical pathway, mucosal immunity (IgA)
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13
Q

how are antibodies recognized?

A

by Fc receptors on different cells

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