lecture 7 Flashcards
The normal immune system is…
tolerant to self-antigens
where is central tolerance induced?
in primar lymphoid organs (thymus, bone marrow) during lymphocyte maturation
mechanisms of central tolerance are
elimination of self-reactive T and B lymphocytes, receptor editing ( B lymphocytes)
peripheral tolerance is induced
when mature lymphocytes recognize self antigens in peripheral tissues under particular conditions
mechanisms of peripheral tolerance are:
anergy, suppression (Tregs) and deletion
What induces anergy?
induced in CD4+ T cells in absence of co-stimulation
anergy is a interaction between
B7 with inhibitory CTLA-4
autoimmunity and autoinflammation is
a failure of self-tolerance
autoimmunity is
an imbalance between lymphocyte activation and control
autoimmunity mechanisms are
genetic (MHC) and environmental (infections)
impact of infections in autoimmunity
expression of co-stimulators and molecular mimicry
autoimmune diseases can be
systemic or organ specific
mechanisms of autoimmune tissue injury
immune complexes, circulating autoantibodies and auto reactive T lymphocytes
