complement system Flashcards

1
Q

what makes up the complement system?

A
  • several plasma proteins which work together
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2
Q

what is the function of the c.s.?

A
  • opsonize microbes
  • promote the recruitment of phagocytes to the site of infection
  • directly kill the microbes
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3
Q

What involves complement activation?

A

proteolytic cascades

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4
Q

how is an active protease formed?

A
  • by an inactive precursor enzyme (zymogen) which is altered
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5
Q

How is the next proteolytic activity induced?

A
  • by cleavage of an active protease
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6
Q

what are the three pathways of complement system?

A
  • classical pathway (induced by antibodies)
  • alternative pathway (microbe)
  • lectin pathway (mannose binding lectin)
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7
Q

what are pentraxins?

A

proteins of pentraxin family → phylogenetically old group of plasma proteins that recognize microbial structures

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8
Q

how strong are plasma concentrations of CRP in healthy individuals?

A

very low

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9
Q

how is CRP synthesis increased?

A

by liver induced by cytokines IL-6 and IL-1

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