Lecture 8 Flashcards
What is Intergrin made of and happens in it’s configuration states?
Made of 2 membrane polypeptide chains
Bent configuration is inactive
upright configuration when bound with Talin activates the protein.
Results in strengthened Cell - ECM interations
What is the 2 major activities of Intergrin? what ways can signaling occur?
Adhesion of cell to ECM / other cells
transmission of signals between environment and cell
signals can be received both inside and out with binding sites
What can outside signals through intergrins influence in a cell?
Differentiation, motility, growth and survival
What are Focal adhesions important for?
Cell adhesion and locomotion
What produces the mechanical forces for Focal Adhesions?
Actin Filaments
What do Hemidesmosomes contain and what do they link to?
Contain keratin filaments that are linked to the ECM through intergrins
what is organ development dependent on?
selective interactions between cells of same type and different types
What 4 factors mediate cell - cell adhesion?
Selectins
Members of the IgSF (immunoglobulin)
members of the intergrin
Cadherins
What are selectins made of and what do they bind to?
Glycoproteins and bind to specific oligosaccharides
What is the structure of Selectins like?
Small portion resides inside cells, spans through the cell-membrane then has a large extracellular portion
What are Selectins involved in?
Cell - Cell adhesion and transmembrane signal transduction
What are IgSF involved in?
Immune functions
adhesion mediators
development in neuronal growth
What is the function of Cadherins?
Binding with other Cadherins in the presence of Ca2+
Most important for assembling tissues
Where can Cadherins be found?
in adheren junctions and desmosomes
Where do tight junctions occur?
between neighboring epithelial cells
