Lecture 7 (Cell - Environment Interaction) Flashcards
What are the 2 important interactions for Cell - Cell and Cell - ECM?
Cell Communication and Cell Adherence
What is a type of connective tissue?
The Dermis
Where are Fibroblasts and are they is their purpose?
On the Dermis
Contain receptors to mediate and transmit messages
What do Carbohydrate projections form on the outer surface of the membrane?
The Glycocalyx
What is the role of the Glycocalyx?
Mediates Cell - Cell and Cell - substance interactions
physical protection
barrier to molecule movement
Regulating factor of binding sites
What does the Extra Cellular matrix surround?
Muscles, nerves and fat cells
What different forms do most proteins take when in the ECM?
Fibrous
What do proteins in the ECM assemble?
A 3D interconnected network
What is Collagen made of and where is it found? Where is it produced?
Fibrous glycoproteins
Present only in the ECM
produced in fibroblasts, smooth muscle and epithelial cells
What helps maintain Collagen fiber?
Proline and Lysine
What is Collagen responsible for?
Insoluble framework for the mechanical properties of the ECM
Tissue properties
What are Proteoglycans and what structure do they have?
A protein - saccharide complex
repeating structure of A-B-A-B
What are Proteoglycans responsible for? What can it form?
creating a -ev charge to attract ions and water.
Can form a Gel
What are the functions of Fibronectin?
Blood clotting, binding to ECM components and cell surfaces, Cell Adhesion and shape
What does Laminin influence?
Cells potential for migration, growth and differentiation
What is the spatially property of the ECM?
ECM fibrils: can stretch up to 7 times their normal length
What is the temporal ECM property?
ECM components continually degrade and reconstruct to allow for ECM remodeling
What degrades ECM components?
Matrix metalloproteinases
what is Matrix metalloproteinases involved in?
Tissue remodeling, embryotic cell migration, wound healing and blood vessel forming
What does abnormal expression of Matrix metalloproteinases result in?
Various diseases
Understand the given example of cell interactions in an animal
tissue – human skin section.
▪
Understand the localization of the ECM relative to cells in an animal
tissue.
▪ Know the basic components and functions of the ECM.
▪ Collagen fibrils form the basic insoluble framework of the ECM.
▪ Laminins form a parallel network.
▪ Proteoglycans are the fillers of the ECM.
▪ Fibronectins and laminins strengthen the ECM.
