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BMSC > Lecture 7 (Cell - Environment Interaction) > Flashcards

Lecture 7 (Cell - Environment Interaction) Flashcards

1
Q

What are the 2 important interactions for Cell - Cell and Cell - ECM?

A

Cell Communication and Cell Adherence

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2
Q

What is a type of connective tissue?

A

The Dermis

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3
Q

Where are Fibroblasts and are they is their purpose?

A

On the Dermis
Contain receptors to mediate and transmit messages

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4
Q

What do Carbohydrate projections form on the outer surface of the membrane?

A

The Glycocalyx

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5
Q

What is the role of the Glycocalyx?

A

Mediates Cell - Cell and Cell - substance interactions

physical protection

barrier to molecule movement

Regulating factor of binding sites

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6
Q

What does the Extra Cellular matrix surround?

A

Muscles, nerves and fat cells

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7
Q

What different forms do most proteins take when in the ECM?

A

Fibrous

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8
Q

What do proteins in the ECM assemble?

A

A 3D interconnected network

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9
Q

What is Collagen made of and where is it found? Where is it produced?

A

Fibrous glycoproteins

Present only in the ECM

produced in fibroblasts, smooth muscle and epithelial cells

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10
Q

What helps maintain Collagen fiber?

A

Proline and Lysine

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11
Q

What is Collagen responsible for?

A

Insoluble framework for the mechanical properties of the ECM

Tissue properties

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12
Q

What are Proteoglycans and what structure do they have?

A

A protein - saccharide complex

repeating structure of A-B-A-B

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13
Q

What are Proteoglycans responsible for? What can it form?

A

creating a -ev charge to attract ions and water.

Can form a Gel

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14
Q

What are the functions of Fibronectin?

A

Blood clotting, binding to ECM components and cell surfaces, Cell Adhesion and shape

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15
Q

What does Laminin influence?

A

Cells potential for migration, growth and differentiation

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16
Q

What is the spatially property of the ECM?

A

ECM fibrils: can stretch up to 7 times their normal length

17
Q

What is the temporal ECM property?

A

ECM components continually degrade and reconstruct to allow for ECM remodeling

18
Q

What degrades ECM components?

A

Matrix metalloproteinases

19
Q

what is Matrix metalloproteinases involved in?

A

Tissue remodeling, embryotic cell migration, wound healing and blood vessel forming

20
Q

What does abnormal expression of Matrix metalloproteinases result in?

A

Various diseases

21
Q

Understand the given example of cell interactions in an animal
tissue – human skin section.
▪
Understand the localization of the ECM relative to cells in an animal
tissue.
▪ Know the basic components and functions of the ECM.
▪ Collagen fibrils form the basic insoluble framework of the ECM.
▪ Laminins form a parallel network.
▪ Proteoglycans are the fillers of the ECM.
▪ Fibronectins and laminins strengthen the ECM.

A

BMSC (22 decks)

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