Lecture 7 Bleeding Disorders Flashcards
Give examples of history of bleeding
Bruising Epistaxis Dental surgery, circumcision, tonsillectomy, appendectomy Menorrhagia Post-partum haemorrhage Post trauma
What pattern of bleeding would platelet type be
Mucosal Epistaxis Purpura Menorrhagia GI
What pattern of bleeding would coagulation factor type present as
Articular
Muscle haematoma
CBS
What is the hereditary pattern of Haemophilia A and B
X-linked recessive
Mother to son
What are the clinical features of Haemophilia
Haemarthrosis Muscle Haematoma CNS bleeding Retroperitoneal bleeding Post-surgical bleeding
What are the clinical complications of haemophilia
Synovitis
Arthropathy
Compartment syndrome
Stroke
How is haemophilia diagnosed
Prolonged APTT time reduction in factor VIII (A) and Factor IX (B)
Genetic analysis
How is haemophilia treated
Coagulation factor replacement FVIII/IX Desmopression Tranexaemic acid (reduced rate of fibrinolysis) Joint replacement Synovectomy Gene therapy
Name some complications of haemophilia treatment
Inhibitory antibodies Anti FVIII
MI
Hyponatraemia (babies)
What type of inheriance is Von Willebrand Disease
Autosomal dominant
What is type 1 Von Willebrand Disease
Quantitative deficiency
What is type 2 Von Willebrand disease
Quantitative and Qualitative abnormalities
What is type 3 Von Willebrand disease
Complete deficiency
How is Von Willebrand treated
VWF concentrate
Desmopressin
Tranexamic acid
OCP
Name the causes of acquired bleeding disorders
Thrombocytopenia Liver failure Renal failure DIC Drugs (warfarin, heparin, aspirin, clopidogrel)
