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Haematology > Lecture 11 Lymphoproliferative Disorders > Flashcards

Lecture 11 Lymphoproliferative Disorders Flashcards

1
Q

Name systemic (B) symptoms of lymphoma

A 
Weight loss
Fever
Night sweats
Pruritis
Fatigue
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2
Q

What is Acute Lymphoblastic Leukaemia

A

Cancerous disorders of lymphoid progenitor

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3
Q

Is there any differentiation into lymphocytes in ALL

A

No

Just uncontrolled growth and accumulation

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4
Q

Describe the clinical presentation of ALL

A 
Impaired vision
Weight loss
Breathlessness
2-3 week joint pain
Bone pain
Sweats
Infections
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5
Q

What do the lab investigations look like for someone with ALL

A 
Low Hb
Elevated WCC (blast cells)
Low platelets
Bone marrow failure
Bone marrow is 90% B-lymphocytes
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6
Q

What are the characteristics of ALL cells

A

Large cells
Express CD19- b cells
CD34, TDT- markers of immature cells

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7
Q

How is ALL treated

A 
Chemo- remission
Consolidation therapy
CNS directed treatment
SCT- high risk
CART
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8
Q

What are the side effects of CART

A

Cytokine release syndrome

Neurotoxicity

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9
Q

What are poor risk factors for ALL

A

Increasing age
Increased WCC
Cytogenetics/molecular genetics t(9;22); t(4;11)
Slow/poor response to treatment

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10
Q

How is ALL treated

A

Multi-agent intensive chemo

Allogenic SCT

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11
Q

What are the characteristics of abnormal cells in Chronic Lymphoid Leukaemia

A

Mature
Resemble normal lymphocytes
Grow slowly (low-grade)

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12
Q

What is the common clinical presentation of CLL

A

Bone marrow failure (thrombocytopenia, anaemia)
Lymphadenopathy
Splenomegaly
Fever and sweats

Less common: hepatomegaly, infections weight loss

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13
Q

Name CLL associated finding

A

Haemolytic anaemia

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14
Q

What is stage A CLL

A

<3 lymph nodes areas

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15
Q

What is stage B CLL

A

3 or more lymph node areas

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16
Q

What is Stage C CLL

A

Stage B + anaemia and thrombocytopenia

17
Q

How is CLL treated

A

Watch and wait
Cytotoxic chemo- Fludarbine
Monoclonal antibodies- Rituximab

18
Q

What are indication for treatment for CLL

A 
Progressive bone marrow failure
Massive lymphadenopathy
progressive splenomegaly
Systemic symptoms 
Autoimmune cytopenias
19
Q

What are poor prognostic markers for CLL

A 
Advanced disease (B or C)
Atypical lymphocyte morphology
rapid lymphocyte doubling
CD38+ expression
P53 mutation
20
Q

What are the clinical presentations of lymphoma

A

B symptoms
Lymphadenopathy/heptaosplenomegaly
Extranodal disease
Bone marrow involvement

21
Q

In the staging of lymphoma what des “A” mean

A

Absence of B symptoms

22
Q

In the staging of lymphoma what does “B” mean

A

Fever, weight loss, night sweats, pruritus

23
Q

Majority of Non-hodgkin lymphoma have what cell origin

A

B cell

24
Q

What type of Non-hodgkin lymphoma has a better prognosis

A

High grade

Required combination chemotherapy

25
Q

What is the commonest subtype of lymphoma

A

Diffuse large-B cell lymphoma

High grade

26
Q

What is the 2nd most common subtype of lymphoma

A

Follicular

Low grade

27
Q

If Follicular lymphoma is not causing any problems what is the first line treatment

A

Watch and wait

28
Q

What is the treatment for follicular and diffuse large B cell lymphoma

A

anti-CD20 monoclonal antibody + chemo

29
Q

What virus is Hodgkin lymphoma associated with

A

Epstein Barr virus

HIV

30
Q

How is Hodgkin Lymphoma treated

A

Combination therapy +/- radiotherapy
Monoclonal antibodies (CD30)
Immunotherapy

31
Q

What are the most commonest symptoms of Hodgkin lymphoma

A

Swelling in the neck, armpit or groin

32
Q

What is stage 1 HL

A

the cancer is limited to 1 group of lymph nodes, such as your neck or groin nodes either above or below your diaphragm (the sheet of muscle underneath the lungs)

33
Q

What is stage 2 HL

A

2 or more lymph node groups are affected, either above or below the diaphragm

34
Q

What is stage 3 HL

A

the cancer has spread to lymph node groups above and below the diaphragm

35
Q

What is stage 4 HL

A

Organ and bone marrow involvement

Haematology (15 decks)

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