Lecture 6 Thrombotic Disorders

Question 1

Define a thrombus

Answer 1

Clot arising in the wrong place

Question 2

Define a thromboemoblism

Answer 2

Movement of clot along a vessel

Question 3

What 3 components of the Virchow’s Triad

Answer 3

Stasis
Hypercoagulability
Vessel damage

Question 4

What is an arterial thrombus

Answer 4

White clot

Platelets and fibrin

Question 5

What are the complications for arterial thrombus

Answer 5

Ischaemia and Infarction

Question 6

What is a venous thrombus

Answer 6

Red thrombus

Fibrin and red cells

Question 7

What are the risk factors for Venous thrombosis

Answer 7

Increasing age
Surgery
Pregnancy
Obesity
Hormonal therapy
Tissue trauma
Immobility
Systemic disease

Question 8

What systemic disease cause venous thrombosis

Answer 8

Cancer
Myeloproliferative Neoplasm
Autoimmune disease (IBD, SLE)

Question 9

How are DVT diagnosed

Answer 9

Wells score
Geneva score
D-dimer
Doppler US
V/Q scan
CT pulmonary angiogram

Question 10

What drugs are used to treat venous thrombosis

Answer 10

LMWH
Warfarin
Direct oral anticoagulants

Question 11

What is Factor V Leiden

Answer 11

Antithrombin deficiency

Question 12

What is Prothrombin G20210A

Answer 12

Protein C deficiency

Protein S deficiency

Question 13

Disseminated Intravascular Coagulation occurs in ____(3)

Answer 13

Septicaemia
Malignancy
Eclampsia

Question 14

What happens to platelets and coagulation factors in DIC

Answer 14

Consumption of platelets and coagulation
Thrombocytopenia
Bleeding

Question 15

What happens to fibrin in DIC

Answer 15

Widespread fibrin deposition
Microvascular thrombosis
Organ failure