Lecture 14 Haemostasis and Thrombosis in Practice Flashcards
- A 20 month old boy attends accident and emergency with his father
- The child has refused to walk for the past 2 days having been walking unsupported for 4 months
- The right knee is slightly swollen and feels warm to touch
- Blood is aspirated from the knee
What is the most likely diagnosis?
Haemophilia A
What factor is deficient in Haemophilia A
Factor VIII
What is the inheritance of Haemophilia
X-linked recessive
What is the main treatment for Haemophilia A
Recombinant factor VII
Administered every day
What are the complications with treatment of haemophilia A
Inhibitory antibodies
- A 24 year old female student presents with a 4 day history of easy bruising and small red spots on her ankles
- She has no previous history of abnormal bleeding
- Previous tonsillectomy with no bleeding
- Recently been off colour with flu like symptoms
- Only medication COCP
- Petechiae
- She has petechiae, menorrhagia, epistaxis easy bruising, and blood blisters in her mouth
What is the diagnosis?
Thrombocytopenia
Name 3 causes of thrombocytopenia
AML
Aplastic anaemia
ITP
What illnesses are associated with Thrombocytopenia
HIV
EBV
SLE
- A 70 year old man has excessive bleeding after a colectomy for cancer
- He has bleeding from his abdominal wound but not from his drain or his indwelling line
- He has had surgery in the past but had no abnormal bleeding
- Which is the most likely cause of this?
Most likely surgical bleeding (single site does not suggest coagulopathic bleeding.
A 65 year old man takes aspirin because of a previous history of TIA. How does aspirin work?
COX-1 inhibitor
What is Factor V Leiden
Is a mutation of one of the clotting factors in the blood. This mutation can increase your chance of developing abnormal blood clots, most commonly in your legs or lungs
