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Host Defense > Lecture 7 > Flashcards

Lecture 7 Flashcards

1
Q

What is the MHC?

A

Set of closely linked genetic loci that are overwhelmingly important in determining fate of gengrafted tissue

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2
Q

Is MHC polymorphic?

A

Highly

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3
Q

Main function of MHC?

A

Presenting peptide to T lymphocytes

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4
Q

What is HLA?

A

Tightly linked gene cluster of cell surface glycoproteins
Regulate immune cell interactions
Evoke allograft rejections

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5
Q

What does HLA stand for?

A

Human leukocyte antigen

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6
Q

What are the class I loci?

A

HLA
HLAB
HLAC

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7
Q

Class II Loci?

A

HLADP
HLADQ
HLADR

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8
Q

Where are class I loci found?

A

Surface of nearly all nucleated cells presenting antigen to CD8+ T cells

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9
Q

Where are class II loci found?

A

DCs
B lymphocytes
Macs
Present to CD4+

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10
Q

What presents to CD?

A

Class I

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11
Q

What presents to CD4?

A

Class II

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12
Q

What are class III loci?

A

Reside in MHC region but no involved in antigen presentation

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13
Q

Where is the HHLA complex found?

A

Short arm chromosome VI

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14
Q

What do class I molecules associate with?

A

Beta2 microglobin in cell membranes?

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15
Q

Where in MHC is B2microglobin coded for?

A

Not in MHC, on different chromosome

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16
Q

What is B2microglobin?

A

Lighter chain on cell surface that associates with class I molecule

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17
Q

Structure of Class I?

A

Alpha chain
Class I polypeptide
B2microglobin

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18
Q

What type of bond does MHC form with antigen?

A

Non covalent

19
Q

What varies amongst MHC molecules?

A

The alpha chain - varies in aa sequence

B2 microglobin is same in them all

20
Q

What portion of MHC crosses cell membrane?

A

C terminus

21
Q

What is class II molecule made of?

A

Alpha chain - 34k daltons

Beta chain - 29k daltons

22
Q

What does MHC I bind?

A

Short peptides 8 - 10 aa in length

23
Q

What does MHC class II bind?

A

13 - 17 aa peptides

24
Q

Where are MHCII alpha/beta and I alpha chains coded for?

A

Different genens on MHC locus

Same chromosome

25
Q

How are MHC genes expressed?

A 
Co dominant manner 
Each person has 3 maternal and 3 paternal class 1 types
Also has 3 maternal and 3 paternal II types
26
Q

What does T cell response depend on?

A

Recognition of presented antigen

Recognition of the MHC it is presented in

27
Q

What is CD8+ specific for?

A

Antigen in MHCI

28
Q

What is CD4+ specific for?

A

Antigen in MHCII

29
Q

What is MHC restriction?

A

Refers to T cells being specific for both antigen AND mhc that presents it

30
Q

What are some APCs?

A

Macs
DCs
B lymphocytes

31
Q

What does cytotoxic T cell do when recognizes MHCI and peptide?

A

Kills cell

32
Q

What is HLA?

A

Major histocompatability complex for humans

33
Q

Would MHC be the same in identical twins?

A

Likely not, highly polymorphic

34
Q

How many polypeptide chains in class I?

A

1

35
Q

How many polypeptide chains in class II?

A

2

36
Q

What domain is antigen binding to?

A

Alpha 1 & 2 helixes

37
Q

What are anchor residues?

A

Highly conserved areas on antigen allowing it to bind to certain MHCI

38
Q

Can MHC bind one or many peptides?

A

Many

39
Q

How is MHC inherited?

A

Strictly mendalian

40
Q

Men or women better organ donors?

A

Women, men have some protein women don?t

41
Q

How many MHC on a cell surface?

A

5k

42
Q

What can MHC convey to a person?

A

Genetic survival advantage

43
Q

What are T cells recognizing I MHC?

A

Non polymorphic region

Host Defense (12 decks)

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