Lecture 3

Question 1

Does innate immunity undergo rearreangments of hypermutation?

Answer 1

NO

Question 2

Are phagocytes innate or adaptive?

Answer 2

Innate

Question 3

Are phagodcytes lymphocytes or leukocytes?

Answer 3

Leukocytes

Question 4

2 main classes of phagocytes?

Answer 4

Macrophages

Neutrophils

Question 5

Macs or neuts live longer?

Answer 5

Macs

Neuts die after eating one meal

Question 6

Which phagocyte found in tissue?

Answer 6

Mac

Question 7

Where are tissue bound phagocytes most promient?

Answer 7

Lung
Skin
Spleen
Liver

Question 8

What is opsonization?

Answer 8

Coating of pathogen by molecules that enhance its ability to be phagocytosed

Question 9

What can be used for opsonization?

Answer 9

• Adaptive antibodies

- Innate complement proteins

Question 10

What do phagocytes produced when activated?

Answer 10

• Cytokines
• Chemokines
• Hydrolytic enzymes
• Antimicrobial peptides
• ** This can occur solely by innate activation by adaptive maximizes this

Question 11

What cells have highly expressed TLRs?

Answer 11

DCs

Macs

Question 12

What is inflammation a product of?

Answer 12

Accumulation of fluid, WBCs, and plasma proteins at site of injury

Question 13

Which immune system responsible for initiation of inflamation?

Answer 13

Innate

Question 14

What is intent of inflammation?

Answer 14

The wall off or destroy infectious agent

Question 15

3 key components of inflammation?

Answer 15

1. Altered blood flow
2. Increased vascular permeability
3. Infiltration of WBCs

Question 16

How is increased vasuclar permeability achieved?

Answer 16

• Contraction of endothelial cells widening intracellular junctions
• Primarily occurs in veinules

Question 17

What marks early inflammation?

Answer 17

Preponderance of neutrophils

Question 18

Order of arrival at inflammation?

Answer 18

1. Neutrophils
2. Macs
3. Lymphocytes

Question 19

What marks chronic inflammation?

Answer 19

Lymphocytes as predominant cell type

Question 20

Where are TLRs primarily found?

Answer 20

DCs
Macs
Monocytes

Question 21

What is final step in path to proinflammator response?

Answer 21

NF kappa beta

Question 22

What does NF kappa beta do?

Answer 22

Activates genes encoding pro inflamatory cytokines

Question 23

What is gateway to adaptive response?

Answer 23

DC

Question 24

Characteristics of DCs?

Answer 24

1. Found in all tissues/organs
2. Multiple PRRs
3. Phagocytosis
4. APCs
5. Direct type of adaptive response
6. Secretion of cytokines to direct adaptive response by shaping lymphocyte differentiation

Question 25

What are NKs derived from?

Answer 25

Lymphoids

Question 26

What are NK cells good at recognizing?

Answer 26

Virus

Tumor

Question 27

What are NKT cells?

Answer 27

• Are not NK cell
• Subset of T cell with TCR restricted for glycolipid antigens
• Function in cell mediated and antibody mediated response

Question 28

What are gamma delta lymphocytes?

Answer 28

• Found in large numbers in GI/Lung mucosa

- Recognize bacterial intermediates in lipid synthesis

Question 29

What is the primary lymphoid tissue?

Answer 29

Bone marrow

Thymus

Question 30

What happens in thymus?

Answer 30

Lymphocytes learn to distinguish self from non self

Question 31

What is secondary lymphoid tissue?

Answer 31

Lymph nodes

Spleen

Question 32

What is recruitment of inflamatory cells characteristic of?

Answer 32

Innate response