Lecture 3 Flashcards
Does innate immunity undergo rearreangments of hypermutation?
NO
Are phagocytes innate or adaptive?
Innate
Are phagodcytes lymphocytes or leukocytes?
Leukocytes
2 main classes of phagocytes?
Macrophages
Neutrophils
Macs or neuts live longer?
Macs
Neuts die after eating one meal
Which phagocyte found in tissue?
Mac
Where are tissue bound phagocytes most promient?
Lung
Skin
Spleen
Liver
What is opsonization?
Coating of pathogen by molecules that enhance its ability to be phagocytosed
What can be used for opsonization?
- Adaptive antibodies
- Innate complement proteins
What do phagocytes produced when activated?
- Cytokines
- Chemokines
- Hydrolytic enzymes
- Antimicrobial peptides
- ** This can occur solely by innate activation by adaptive maximizes this
What cells have highly expressed TLRs?
DCs
Macs
What is inflammation a product of?
Accumulation of fluid, WBCs, and plasma proteins at site of injury
Which immune system responsible for initiation of inflamation?
Innate
What is intent of inflammation?
The wall off or destroy infectious agent
3 key components of inflammation?
- Altered blood flow
- Increased vascular permeability
- Infiltration of WBCs
How is increased vasuclar permeability achieved?
- Contraction of endothelial cells widening intracellular junctions
- Primarily occurs in veinules
What marks early inflammation?
Preponderance of neutrophils
Order of arrival at inflammation?
- Neutrophils
- Macs
- Lymphocytes
What marks chronic inflammation?
Lymphocytes as predominant cell type
Where are TLRs primarily found?
DCs
Macs
Monocytes
What is final step in path to proinflammator response?
NF kappa beta
What does NF kappa beta do?
Activates genes encoding pro inflamatory cytokines
What is gateway to adaptive response?
DC
Characteristics of DCs?
- Found in all tissues/organs
- Multiple PRRs
- Phagocytosis
- APCs
- Direct type of adaptive response
- Secretion of cytokines to direct adaptive response by shaping lymphocyte differentiation
What are NKs derived from?
Lymphoids
What are NK cells good at recognizing?
Virus
Tumor
What are NKT cells?
- Are not NK cell
- Subset of T cell with TCR restricted for glycolipid antigens
- Function in cell mediated and antibody mediated response
What are gamma delta lymphocytes?
- Found in large numbers in GI/Lung mucosa
- Recognize bacterial intermediates in lipid synthesis
What is the primary lymphoid tissue?
Bone marrow
Thymus
What happens in thymus?
Lymphocytes learn to distinguish self from non self
What is secondary lymphoid tissue?
Lymph nodes
Spleen
What is recruitment of inflamatory cells characteristic of?
Innate response
