Lecture 5 - Gastrointestinal Disease 1 Flashcards

1
Q

What are the typical symptoms of gastrointestinal disease?

A

Vomiting
Diarrhoea
Fever
Abdominal pain

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2
Q

What is the difference between diarrhoea and dysentery?

A

Diarrhoea: no blood
Dysentery: blood, due to inflammation

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3
Q

Why will gastrointestinal disease cause death?

A

Due to fluid loss

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4
Q

What is the difference in prognosis of gastrointestinal disease in different parts of the world?

A

Developed world:

  • self-limiting
  • not life threatening

Non-developed world:

  • can be life threatening
  • leads to malnutrition, growth retardation
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5
Q

What is the definiation of a reservoir?

A

A living thing in which an infectious agent normally lives and multiplies

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6
Q

What are the main sources of infection for gastrointestinal disease?

A
Faeces
Fingers
Food
Fluids
Fornication
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7
Q

Discribe how the faecal-oral route may lead to infection?

A

Human / animal faeces contaminates food / water

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8
Q

Can people who aren’t presenting with symptoms of the disease be excreting the pathogen?

A

Yes

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9
Q

Which bacteria to poultry excrete?

A

Campylobacter

Salmonella

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10
Q

Which bacteria to cattle excrete?

A

Salmonella

E. coli

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11
Q

Which bacteria do pigs excrete?

A

Yersinia

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12
Q

How can we thwart faecal contamination of food?

A

Proper cooking techniques

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13
Q

Give some examples of how contaminated fluids can cause disease

A

Cholera: drinking contaminated water

Vibrio parahaemolyticus: oysters take in the bacteria

Giardia: swimming in contaminated water

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14
Q

How do ‘fingers’ play a role in disease?

A

They can convey microbes into the mouth

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15
Q

How may the habits of the food handler affect disease?

A

Normal flora from the handler can cause disease

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16
Q

What are fomites?

A

Inanimate objects with bacteria on them

17
Q

What are the features of intoxication?

A
  • Quick onset
  • Not neutralised by cooking –> heat stable
  • Mainly vomiting
18
Q

What factors affect the likelyhood of bacteria surviving the GIT to cause disease?

A
  • Use of antacids
  • Dysbiosis
  • Protection with food; chocolate, cheese
19
Q

Which infections cause dysentery?

A

Shigella

Entamoeba histolytica

20
Q

Which viruses cause watery diarhoea?

A

Cholera
Rotavirus
ETEC

21
Q

If there is inflammation of the GIT, there will be…

A

Bloody diarrhoea

22
Q

What is classed as long and short incubation period?

A

Short: 2-6 hours

Long: 12-48+ hours

23
Q

Which pathogens have a low infectious dose? Why?

A

Shigella, it is acid stable

24
Q

Which pathogens have a high infectious dose?

A

ETEC

25
Q

Which specimens are used for investigation of gastrointestinal disease?

A

Faeces
Food
(Vomit)

26
Q

Which lab procedures are used to investigate infections?

A

1/ Microscopy
- light, electron

2/ Latex agglutination, EIA (enzyme immuno assay)

3/ PCR, gel electrophoresis