CD4+ T Cell Differentiation Pathways Flashcards
1
Q
When is TGF-beta released as Signal 3?
A
• When self antigen is presented in MHC (ie no pathogen)
or
• Early in infection
2
Q
What does TGF-beta stimulate?
A
Treg
3
Q
Which cytokines does Treg release?
A
- IL-10
* TGF-beta
4
Q
When is IL-6 released?
A
• Early in infection
5
Q
What does IL-6 + TGF-beta stimulate?
A
Th17
neutrophil recruitment
6
Q
Which cytokines does Th1 release?
A
- IL-6
* IL-17
7
Q
Which cytokines are released if infection persists?
A
IL-12
8
Q
What does IL-12 stimulate?
A
Th1
• macrophage activation
• Antibody, IgG
9
Q
Which cytokines does Th1 release?
A
- IFN-gamma
* TNF
10
Q
What does IL-4 + IL-33 result in?
A
Th2 • Mast cells • Eosinophils • IgE (allergy, parasite immunity)
11
Q
Which cytokines does Th2 release?
A
- IL-4
* IL-5
12
Q
What does IL-6 stimulate?
A
• Tfh
(B cell help)
• Th17
(neutrophils)
13
Q
Which cytokines does Tfh release?
A
IL-21
