Lecture 4 - Protein Structure and Synthesis Flashcards
1
Q
What are Proteins
A
Linear chains of Amino Acids
2
Q
What are Intrinsically Disordered Proteins
A
proteins that have lost their native and functional folding resulting in an insoluble aggregation in many organs
3
Q
What can an accumulation of Intrinsically Disordered Proteins (IDP) lead to
A
- Neurotoxic effects in neurodegenerative diseases
- Beta Amyloid Proteins
4
Q
How many different amino acids form proteins
A
20
5
Q
What type of bonds link amino acids together in proteins
A
Covalent Peptide Bonds
6
Q
What are 2 examples of quaternary structures?
A
- Haemoglobin
- Tubulin
7
Q
What are the 2 stages of protein synthesis?
A
- Transcription
- Translation
8
Q
What are the 3 phases of DNA Transcription?
A
Initiation
Elongation
Termination
9
Q
What happens during splicing
A
- large assembly of RNA
- Protein is cut out
- Introns and extrons are joined together
