lecture 39 - obesity

Question 1

What BMI is classified as obese?

Answer 1

above 30.0

Question 2

What are the 3 components of energy expenditure?

Answer 2

Resting metabolic rate, physical activity/exercise, adaptive thermogenesis

Question 3

What is the most variable component of energy expenditure?

Answer 3

Physical activity

Question 4

What is the most well known chemical that causes ATP uncoupling?

Answer 4

DNP

Question 5

What is the role of uncoupling proteins in mitochondria?

Answer 5

They make the membrane of mitochondria leaky to H+, uncoupling them from producing ATP via ATP synthase after electron transport because a electrochemical gradient cannot be sustained.

Question 6

What type of fat contains uncoupling proteins?

Answer 6

Brown fat

Question 7

What is the result of uncoupling proteins making mitochondria leaky in brown fat?

Answer 7

ATP is not produced, and heat is produced via fatty acid oxidation regardless of ATP use by the brown fat tissue

Question 8

What is the symbol for an uncoupled protein?

Answer 8

UCP

Question 9

What must bind to UCP (uncoupling protein) to switch it ‘off’?

Answer 9

GDP

Question 10

Where is leptin produced?

Answer 10

White fat cells

Question 11

what does leptin signal to the brain?

Answer 11

Signals to it to stop eating

Question 12

Where are leptin receptors foudn in the brain?

Answer 12

The hypothalamus

Question 13

What are the 2 possible causes of obesity caused by issues with leptin?

Answer 13

Lack of leptin production or resistance to leptin due to receptor disfunction