Lecture 33 - Drugs for Motility Disorders

Question 1

Metoclopramide and Domperidone are both _________ antagonists. They block the inhibitory effect of _____ on Ach in the GI smooth muscle. This is a good treatment for ______, as it would increase tone/contraction of LES smooth muscle.

What is significant about these medications’ ability to act on the intestines?

Answer 1

Dopamine D2-receptor antagonists

Dopamine

GERD

They don’t!

Question 2

Adverse effects of Metoclopramide and Domperidone include _____ and _____, as well as exacerbation of ______ disorders in the elderly.

Answer 2

Anxiety and Insomnia

Movement

Question 3

PEG is considered a _____ (weak, mild, or strong?) osmotic lax, and it is coadministered with electrolytes.

Answer 3

Strong

Question 4

Anthraquinone is a cathartic laxative derived from ______.

Answer 4

Aloe

Question 5

Alvimopan and Methylnaltrexone are ______ –> treat opioid-induced constipation without affecting opioid pain reduction.

Answer 5

PAMORAs

Question 6

Lupiprostone is a fatty acid that acts as a ____ secretion activator. Bc it is a fatty acid, it acts ______ (intra or extracellularly?) on Cl channels.

Answer 6

Cl secretion activator

Intracellularly

Question 7

Linaclotide and Plecanatide are ______, so they act extracellularly on lumenal receptors. They increase intracellular ______ –> activates CFTR.

Answer 7

Peptides

cGMP

Question 8

While SST has a half-life of ___mins, Octreotide administered IV has a half-life of ___hrs, and administered subQ has a half-life of ____hrs.

______ is an SST analogue given orally.

Answer 8

2 mins

2 hrs

12 hrs

Sandostatin