Lecture 34 - GI and COVID-19

Question 1

COVID-19 ______ protein binds its RNA genome and creates a circular string-like formation. The _____ protein is what binds host cell receptors, where it is cleaved by TMPRSS2 into 2 subunits. Which subunit binds ACE2?

_______-_____ dimer protein likely enhances viral entry, while the ______ protein facilitates assembly and release.

Answer 1

Nucleocapsid

Spike

S1 binds ACE2

Hemagglutinin-esterase dimer protein

Envelope

Question 2

_____ is the serine protease responsible for changing the conformation of the RBD in the S1 subunit of newly produced spike proteins in infected cells. THIS IS SPECIFIC TO Sars-CoV-2!!!

Answer 2

Furin

Question 3

How does ACE2 normally act?

Answer 3

It converts angiotensin II (vasoconstrictor) into angiotensin I (vasodilator)

Question 4

Remember that intestinal expression of _____ is dependent on co-expression of ACE2 –> absence of _____ leads to Hartnup’s disease.

Answer 4

B0AT1

B0AT1

Question 5

Diets high in _____ increase the expression of ACE2.

Answer 5

Protein