Lecture 32

Question 1

CAT-I (CPT-I) function:

Answer 1

Controls the rate of fatty acid oxidation. (It negatively regulated by malonyl-CoA an intermediate of fatty acid biosynthesis.

Question 2

How is Fatty acid oxidation regulated? first 2 steps.

Answer 2

• CAT-I is inhibited during fed state. The commited intermediate in the fatty acid biosynthesis: Malonyl-CoA which is a signal the fed state.
• Malonyl- CoA inhibits CAT-I, thus inhibiting the entry of acyl groups into the mitochondrial matrix

Question 3

How is fatty acid oxidation regulated? steps 3 and 4

Answer 3

• Instead of fatty acids are incorprated into VLDL as triglycerols and transported to the adipocyte for storage.
• During fasted stage, fatty acids are impored from adipose and because of the lack of malonyl CoA, CAT-I is the active and B-Oxidation generates energy from fat.

Question 4

How many ATPs does each round of fatty acid oxidation makes?

Answer 4

5 ATPS and 131 in total yield of all rounds.