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Biochemistry exam 3 > Exam 3 questions from lecture Ashley > Flashcards

Exam 3 questions from lecture Ashley Flashcards

1
Q
  1. Which statement is correct?
    a. All enantiomers are stereoisomers
    b. All stereoisomers are enantiomers
    c. All diastereomers are enantiomers
    d. All enantiomers are diastereomers
A

A

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2
Q
  1. The milk sugar:
    a. Is a disaccharide containing glucose & fructose
    b. Can be properly digested in the oral cavity
    c. Is a substrate of isomaltase
    d. Is a reducing sugar
A

D

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3
Q
  1. Which of the following is an active transporter critically involved in intestinal glucose absorption?
    a. GLUT-5
    b. SGLUT-1
    c. GLUT-3
    d. GLUT-4
A

B

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4
Q
  1. Which of the following is not a difference between hexokinase & glucokinase?
    a. Tissue expression patterns
    b. Require magnesium for activity
    c. Km
    d. Inhibition by glucose-6-phosphate
A

B

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5
Q
  1. Which of the following is a feature of muscle phosphofructokinase (PFK1)?
    a. PFK-1 is activated by ATP
    b. The function of PFK-1 requires the cofactor thiamin pyrophosphate TPP
    c. The reaction catalyzed by PFK-1 consumes ATP
    d. The reaction catalyzed by PFK-1 takes place in the mitochondria
A

C

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6
Q
  1. Which of the following glycolytic enzymes generate ATP through substrate level phosphorylation?
    a. Phosphofructokinase-1 (PFK-1) & pyruvate kinase (PyrK)
    b. Phosphoglycerate kinase (PGK) & pyruvate kinase (PyrK)
    c. Aldolase & pyruvate kinase (PyrK)
    d. Hexokinase & phosphofructokinase-1 (PFK-1)
A

B

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7
Q
  1. Identify the single CORRECT statement about lactate dehydrogenase (LDH)?
    a. It mediates the interconversion between pyruvate & lactate
    b. It is used by yeast under anaerobic conditions
    c. It mediates a substrate-level phosphorylation
    d. It requires oxygen for catalysis
A

A

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8
Q
  1. The sequence of reactions mediated by pyruvate dehydrogenase complex (PDC):
    a. Takes place in the cytosol
    b. Are fully reversible
    c. Are activated by PDC E1 phosphatase
    d. Are activated by PDC E1 kinase
A

C

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9
Q
  1. Which of the following is not a high-energy compound (can be used to generate ATP) formed during glucose metabolism?
    a. 1,3-bisphosphoglycerate
    b. Pyruvate
    c. Phosphoenolpyruvate
    d. Succinyl-SCoA
A

b

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10
Q
  1. The sequence of reactions mediated by pyruvate dehydrogenase complex (PDC):
    a. Takes place in the cytosol
    b. Are fully reversible
    c. Are activated by PDC E1 phosphatase
    d. Are activated by PDC E1 kinase
A

c

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11
Q
  1. The TCA intermediate that is consumed by citrate synthase but produced by malate dehydrogenase is:
    a. Succinate
    b. Malate
    c. Oxaloacetate
    d. Isocitrate
A

c

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12
Q
  1. Which of the following enzymes is involved in NADH electron shuttling?
    a. Citrate synthase
    b. Isocitrate dehygrodenase
    c. Malate dehydrogenase
    d. Fumarase
A

c

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13
Q
  1. Which of the following statements is CORRECT regarding cytochrome c of the electron transport chain?
    a. It contains heme
    b. It receives electrons from Complex I of the ETC
    c. It is a component of Complex V
    d. It is a membrane protein
A

A

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14
Q
  1. 2, 4-dinitrophenol (2,4-DNP) was once used as an anti-obesity pill. A subject taking DNP is expected to exhibit:
    a. Decreased metabolic rate
    b. Reduced activity of Complex V
    c. Reduced electron flow
    d. Increased proton gradient across the inner mitochondrial membrane
A

b

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15
Q
  1. Active mitochondria are incubated in an oxygenated chamber. When adenosine diphosphate (ADP) is added to the chamber, oxygen consumption increases. This is because:
    a. ADP is an inhibitor of Complex III of the electron transport chain
    b. ATP is synthesized through substrate-level phosphorylation
    c. ADP is transported across the inner mitochondrial membrane
    d. ADP stimulates the activity of Complex V
A

D

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16
Q

Streptococcal dextransucrase plays a prominent pathogenic role in dental caries. Which of the following is NOT linked to the enzyme reaction products?

a. Production of biofilm
b. Bacterial adhesion in the oral cavity
c. Dental fluorosis
d. Bacterial evasion of host immunity

A

C

17
Q

e. Which of the following is NOT correct about saliva?
i. It contains the anti-bacterial enzyme lysozyme
ii. It contains calcium & phosphate for remineralization
iii. It contains the glycolytic enzyme lactoperoxidase
iv. It contains bicarbonate as a pH buffer

A

C

18
Q
  1. Fluoride is an active ingredient of toothpaste. Which of the following is NOT a feature or effect of excessive fluoride exposure?
    a. Activation of saliva lysozyme
    b. Inhibition of bacterial enolase
    c. Formation of an apatite
    d. Osteosclerosis
A

A

19
Q
  1. The densities of lipoprotein particles increase with increasing contents of which of the following?
    a. Proteins
    b. Triglycerides
    c. Cholesterol esters
    d. Phospholipids
A

A

20
Q
  1. The activity of lipoprotein lipase (LPL) is stimulated by which of the following proteins?
    a. ApoCII
    b. Colipase
    c. ApoB48
    d. ApoE
A

A

21
Q
  1. Lipitor works by:
    a. Increasing cholesterol uptake through LDL receptor
    b. Activating the breakdown of cholesterol through HMG-CoA reductase
    c. Preventing the synthesis of cholesterol through HMG-CoA reductase
    d. Decreasing cholesterol uptake through LDL receptor
A

C

22
Q
  1. Which of the following statements is true for saturated & unsaturated fatty acids containing the same amount of carbons?
    a. The oxidation of either will produce the same amount of energy
    b. The oxidation of the saturated fatty acid produces additional FADH2
    c. The oxidation of the unsaturated fatty acid produces additional FADH2
    d. The oxidation of the unsaturated fatty acid produces additional NADH
A

B

23
Q
  1. Which of these enzymes is responsible for a mode of intersystem regulation between glycolysis & fatty acid oxidation?
    a. Fatty acyl-CoA synthetase
    b. Phosphofructokinase
    c. Malate dehydrogenase
    d. Aspartate transaminase
A

D

24
Q
  1. Which of the following enzymes is specifically inhibited by malonyl-CoA?
    a. Carnitine acyltransferase-I (CAT-I)
    b. Acyl-CoA carrier protein (ACP)
    c. Fatty acyl-CoA dehydrogenase
    d. Carnitine acyltransferase-II (CAT-II)
A

A

25
Q
  1. The enzyme ß-hydroxybutyrate dehydrogenase:
    a. Is involved in the activation of ketone bodies
    b. Is responsible for decarboxylation of ketone bodies
    c. Mediates the interconversion between acetoacetate & ß-hydroxybutyrate
    d. Is present exclusively in the brain
A

C

26
Q
  1. Adipose hormone sensitive lipase (HSL):
    a. Is most active in the fed state
    b. Is activated by insulin
    c. Is an extracellular enzyme
    d. Is activated by protein kinase A (PKA)
A

D

27
Q
  1. The Atkins diet, which is a high fat, high protein & low carbohydrate diet, is based on the theory that overweight people eat too many carbohydrates. Which of the following may be caused by Atkins diet?
    a. A high concentration of lactate in the blood resting state
    b. A high concentration of acetoacetate in the blood
    c. A low concentration of ß-hydroxybutyrate in the blood
    d. A low concentration of methylmalonate in the blood
A

B

28
Q
  1. Skeletal muscle is unable to transport its products from glycogenolysis to other tissues because:
    a. It lacks phosphoglucomutase
    b. It lacks hexokinase
    c. It lacks GLUT1
    d. It lacks glucose-6-phosphatase
A

D

29
Q
  1. The driving force for glycogenesis is:
    a. Cleavage of pyrophosphate (PPi)
    b. A high level of inorganic phosphate (Pi)
    c. Secretion of glucagon
    d. Activation of glycogen phosphorylase
A

A

30
Q
  1. Protein Kinase A (PKA) directly:
    a. Inactivates glycogen synthase & activates glycogen phosphorylase
    b. Activates glycogen synthase & inactivates glycogen phosphorylase
    c. Inactivates glycogen synthase & activates phosphorylase kinase
    d. Activates glycogen synthase & inactivates phosphorylase kinase
A

C

31
Q
  1. Which of the following is expected to promote gluconeogenesis in the fasted state?
    a. Activation of pyruvate carboxylase by acetyl-CoA
    b. Activation of phosphoprotein phosphatase-1 (PP-1) by insulin
    c. Reduced synthesis of phosphoenolpyruvate carboxykinase (PEPCK)
    d. Decreased activity of protein kinase A (PKA)
A

A

32
Q
  1. Which of the following is not activated by glucagon?
    a. Gluconeogenesis
    b. Glycogenesis
    c. Glycogenolysis
    d. Fatty acid oxidation
A

B

33
Q
  1. Which of the following is associated with downregulation of substrate cycling?
    a. Hyperthyroidism
    b. Cold sensitivity
    c. Increased ATP hydrolysis
    d. Muscle wasting
A

B

34
Q
  1. Which of the following processes is associated with the regulatory and rate-limited step of the pentose phosphate pathway?
    a. Decarboxylation
    b. Substrate-level phosphorylation
    c. NADPH production
    d. ATP production
A

C

35
Q
  1. Which of the following does NOT require the function of NADPH?
    a. Gluconeogenesis
    b. Fatty acid biosynthesis
    c. Cholesterol biosynthesis
    d. Cellular defense against oxidative stress
A

A

36
Q
  1. The hemolytic anemia resulting from G6PD deficiency is primarily due to decreased function of:
    a. Cytochrome P450
    b. Glutathione reductase
    c. NADPH oxidase
    d. Heme oxygenase
A

B

37
Q
  1. The mitochondrial acetyl-CoA pool cannot be used for which of the following?
    a. TCA & ketogenesis
    b. Fatty acid synthesis & TCA
    c. Fatty acid synthesis & protein acetylation
    d. Ketogenesis & protein acetylation
A

C

38
Q
  1. Insulin-mediated dephosphorylation of acetyl-CoA carboxylase (ACC):
    a. Occurs in the fasted state
    b. Inactivates the enzyme
    c. Requires the activity of protein phosphatase-1 (PP-1)
    d. Is essential for fatty acid oxidation
A

C

39
Q
  1. Which of the following is not a target for a drug used to treat Type II diabetes?
    a. SGLT2
    b. AMPK
    c. PPARγ
    d. VEGF
A

D

Biochemistry exam 3 (15 decks)

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