Lecture 3 Connective Flashcards
Connective tissue 2 components
Extracellular matrix (ECM) and cells
Extracellular matrix (ECM) 2 components
Ground substance, and Fibrous proteins (secreted by cells in ECM)
What is ground substance made of?
water, polysaccharides (glycosaminoglycans), proteins
What are glycosaminoglycans?
Long unbranched sugars made from repeating disaccharide units (e.g glucuronic acid, N acetylglucosamine)
Proteoglycans
Core protein + glycosaminoglycan
Sulphated GAGs
Dermatan, Keratan, Heparin, Chondroitin
Non sulphated GAG
Hyaluronic Acid
Applications of Hyaluronic Acid
Viscous, slippery binds cells together, lubricates joints, maintains eye-ball shape
3 types of fibrous proteins
Collagen Fibres, Reticular (collagen type III) fibres, Elastic fibres
Application of sulphated GAGs
Keratan: Strengthens bone, cartilage; lubricates cornea of eyes
Dermatan: Skin, Tendons, heart valves, blood vessels
Chondroitin: adhesive features in bone, cartilage, skin, blood vessels
Heparin
Periorbital deposition and Thyroid disease
Over stimulation of thyroid gland (swells) –> over activation of fibroblasts –> increased secretion of fibrous proteins + increased GAGs and water –> orbital content increases causing enlargement of eye.
Marfans Syndrome
Mutation of gene coding for Fibrillins on Chromosome 15 –> Transforming Growth Factor beta (TFGb) can’t bind properly to Fivrillin –> Fibrillin remains active so increased growth
Marfans Syndrome symptoms
Tall, long limbs, collapsed or protruding sternum, weakened heart valves + blood vessels
2 common CT tissue cell types
Fibroblasts; Adipocytes
Other CT tissue cell types
Macrophage (wanderer), Plasma cell (antibodies), Mast cell (histamine), Leucocyte (white blood cell, phils and cytes)
Plasma cells
Differentiated from B-lymphocytes, and produce antibodies. Found particularly in gut, spleen, lungs, salivary glands lymph nodes, RBM.
Mast cells
Produce histamine which dilates blood vessels, obv found in blood vessels
Macrophage
Differentiated from Monocytes. Wandering in CT at sites of III (infection, injury, inflammation) or fixed as specialised:
Dust cells in lungs, Kupffer cells in liver, Langerhan’s cells in skin
Leucocytes
White blood cells including neutrophil, eosinophil, basophil, lymphocyte, monocyte
Two classifications of CT
Embryonic, Mature
Two types of embryonic CT
Mesenchyme (embryonic), Mucous