Lecture 3 Flashcards
What impairs/blocks nerve conduction?
cold pressure impairs impulse conduction = interrupts blood circ = no o2
sedatives and anaesthetics block nerve impulses by altering membrane permeability = no Na+ entry = no AP
Why do fibers with myelin sheaths transmit signals faster?
nerve impulses jump from node to node
What is an example of a poison that blocks nerve impulse?
tetrodoxin - produced by pufferfish
What is a synapse?
neurotransmitter chemical crosses gap to transmit signal from one neuron to the next
neurotransmitter binds to receptor on the next neuron
What are the two types of synapses?
most neurons communicate via chemical synapses
there are also physical synapses
What are the steps to a chemical synapse?
- AP reaches axon terminal
- electrical change opens Ca2+ channels
- vesicles containing neurotransmitter fuse with axon membrane and release transmitter
- neurotransmitter diffuses across synapse to bind to receptors on next neuron
- series of events from before occurs
After a synapse what happens to the neurotransmitter?
neurotransmitter is removed from synapse either by diffusion away by reuptake into the axon terminal or by enzymatic break down
What are the four classes of neurotransmitters?
AA: glutamate, aspartate, glycine, GABA
Monoamines: catecholamines like dopamine, adrenalin and noradrenalin, seratonin
Acetylcholine
Neuroactive peptides: endogenous opioids, peptides from hypothal/pit gland
Where does acetylcholine work?
crosses the neuromuscular junctions
ACh excites the muscle-cell membrane, causing depolarization and contraction of the muscle fibre
What happens if ACh is not released?
muscle cannot contract
What does cholinesterase do?
breaks down Ach
Draw out table of neurotransmitters
slide 14
What is the function of serotinin/5-hydroxytryptamine (5-HT)
involved in eating, circadian rhythmicity, neuroendocrine, function sleep, mood, anxiety
What is 5-HT synthesized from?
tryptophan
What is 5-HT an intermediate of?
transformation of tryptophan to serotonin
What is the action of a serotonergic drug?
selective serotonin reuptake inhibitor prolongs the action of 5-HT in the synapse by preventing its uptake
What is mucosal 5-HT present in?
entero-chromaffin ccells of the mucosal epithelium triggers persitaltic and secretory reflexes through the activation of enteric and sensory neurons
What occurs in birds with lower levels of 5-HT?
feather pecking
How many cranial nerves are there?
12 cranial nerves
What are the 12 cranial nerves?
- olfactory
- optic
- oculomotor
- trochlear
- trigeminal
- abducens
- facial
- auditory
- glossopharyngeal
- vagus
- spinal accessory
- hypoglossal