Lecture 29 4/7/25 Flashcards

1
Q

What are the available treatment options for medical therapy in ruminants?

A

-fluid therapy
-antimicrobials
-pain/inflammation management
-prokinetics
-good quality pasture and forage

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2
Q

What is the most common metabolic derangement in adult ruminants with GI dz?

A

hypochloremic metabolic alkalosis

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3
Q

What are the exceptions to metabolic alkalosis being the most common metabolic derangement?

A

-strangulating bowel lesions/intestinal ischemia
-enteritis
-ruminal acidosis
-urinary tract dz
-calves

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4
Q

What should be assessed for on PE of an animal with a GI disorder?

A

-BCS
-fluid deficit
-increased CRT
-MM color
-cool extremities

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5
Q

How is % dehydration calculated based on skin turdor?

A

% dehydration = 2 x (tent time in seconds) -4

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6
Q

How is % dehydration calculated based on eyeball recession?

A

% dehydration = eyeball recession in mm x 2

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7
Q

What are the characteristics of animals with 1 to 5% dehydration?

A

-eyeball recession of 0 to 3 mm
-neck skin tent lasts 1 to 4 seconds
-MM are moist
-treated with oral fluids

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8
Q

What are the characteristics of animals with 6 to 8% dehydration?

A

-eyeball recession of 3 to 4 mm
-neck skin tent lasts 5 to 10 seconds
-MM are tacky
-treated with oral fluids

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9
Q

What are the characteristics of animals with 9 to 10% dehydration?

A

-eyeball recession of 4 to 6 mm
-neck skin tent lasts 11 to 15 seconds
-MM are tacky to dry
-treated with IV fluids

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10
Q

What are the characteristics of animals with 11 to 12% dehydration?

A

-eyeball recession of 7 to 8 mm
-neck skin tent lasts 16 to 45 seconds
-MM are dry and cold
-treated with IV fluids

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11
Q

What are the typical findings on blood work that indicate dehydration?

A

-total protein increases; typically a 0.1 g/dL inc. indicates a 1% decrease in body water
-USG > 1.020

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12
Q

What are the characteristics of oral fluid therapy?

A

-for less severe dehydration
-inexpensive
-quick
-absorption varies
-contraindicated in mechanical obstructions
-should not give more than 5 to 10 gal.
-should contain NaCl, KCl, and/or CaCl2

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13
Q

What are the characteristics of IV fluid therapy?

A

-for severe dehydration
-expensive
-time consuming
-want to correct specific abnormalities
14 g catheter can allow for 20 L/hour rate

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14
Q

How is the fluid deficit calculated?

A

body weight in kg x % dehydration

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15
Q

What is YMCP?

A

compound that can be used for fluid therapy that contains yeast, magnesium, calcium, and potassium

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16
Q

What can be used for an oral fluid drench?

A

-rumen fluid
-alfalfa meal
-propylene glycol (propionate production)
-calcium
-potassium chloride

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17
Q

What can be added to fluid therapy for adult cattle?

A

-calcium
-KCl
-glucose (if pregnant/lactating)
-rumen fluid

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18
Q

What are the acidifying solutions for fluid therapy in cattle?

A

-0.9% NaCl
-5 to 7% NaCl

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19
Q

What are the characteristics of combo fluid therapy?

A

-common in adults
-can reduce a severe dehydration to a mild/moderate dehydration
-involves hypertonic saline and oral fluids
-2 L given IV first, then a 5 gal. drench orally

20
Q

What are the mechanisms of metabolic acidosis in neonates?

A

-dehydration
-bacterial fermentation
-loss of bicarb. rich fluid

21
Q

How does dehydration lead to metabolic acidosis in calves?

A

-profuse diarrhea leads to loss of electrolytes and water
-severe dehydration causes poor perfusion
-poor perfusion leads to poor oxygen delivery to tissues and increased lactic acid production
-lactic acid cannot be metabolized by the liver easily due to poor perfusion

22
Q

How does bacterial fermentation lead to metabolic acidosis in calves?

A

-bacterial fermentation in GI tract leads to high uptake of D-lactic acid
-D-lactic acid cannot be metabolized; must be excreted with fluids

23
Q

How is metabolic acidosis corrected?

A

fluids and bicarbonate admin.

24
Q

What are the clinical signs of metabolic acidosis?

A

-depression and CNS dysfunction
-altered mentation
-loss of suckle reflex
-ataxia
-weakness
-recumbency

25
What can cause a poor suckle reflex?
-shock -hypoglycemia -D-lactic acidosis
26
What are the ongoing losses in calves based on the diarrhea severity?
-mild: 1 to 2 L -moderate: 3 to 4 L -severe: 5 to 6 L
27
What is the fluid maintenance requirement for calves?
50 to 100 ml/kg/day (typically around 60)
28
What are some determining factors of whether calves get oral vs IV fluids?
-age -hydration status -mentation
29
What are the characteristics of oral fluids in calves?
-must have suckle reflex -alternate with milk feeding/add as extra "meal" -add in acetate and propionate -given once a day with 60-80 mEq/L
30
What are the characteristics of SQ fluids in calves?
-producer friendly -absorption takes 1 to 2 hours -isotonic fluids only -only for calves; not adults
31
What are the characteristics of IV fluids in calves?
-severe dehydration -shock -compromised GI -D-lactic acidosis -provides more control -expensive -time consuming -can replenish for 2 to 6 hours and then switch to oral
32
What are the 4 key ingredients for good oral electrolytes?
-enough Na to replace losses -co-transport molecules -alkalinizing agent -energy source
33
Why should bicarb. in oral fluids be avoided in calves?
-HCO3 directly buffers acid and can affect abomasal pH -buffering of abomasal pH reduces defense barrier for pathogens -also reduces the milk clot which can reduce digestion
34
What are the alkalizing solutions used for calf fluid therapy?
-normasol -plasmalyte -LRS -isotonic NaHCO3
35
How is total body HCO3 excess calculated?
total body HCO3 excess = [base excess (mEq/L)] x [BW (kg)] x 0.5
36
How is the base deficient determined?
take the patient's base measurement minus the normal of 24 mEq/L
37
What is a negative effect of giving bicarb. in acidotic animals w/ concurrent resp disease?
it can lead to the production of H2O and CO2, which can make an acidotic animal more acidotic when not respirating well
38
How can you assess for success of fluid therapy treatment?
-urine output of 1-2 ml/kg/hr -creatinine drops by half within 12 to 24 hours -overal clinical improvement
39
What are the characteristics of strong ion difference?
-calculated by taking (K + Na) - Cl -< 40 is an acid -> 40 is alkaline
40
What are the characteristics of balanced electrolyte solutions?
-minimal acid-base disturbance -strong ion difference is near the normal of 40 to 45
41
When should antibiotic therapy be considered for GI disorders?
-evidence of systemic dz -evidence of Salmonella or Clostridium infections
42
What are the best recommendations for antibiotic therapy?
-parenteral oxytet. -parenteral ampicillin -oral amoxicillin/clavamox/PPG (calves) -ceftiofur
43
Why are parenteral antibiotics preferred over oral?
-oral antibiotics can disrupt rumen flora -oral antibiotics can cause normal rumen flora to re-populate small intestine -antibiotic boluses likely end up in rumen
44
What are the options for pain/inflammation management?
-NSAIDs -opioids -ketamine -alpha-2 agonists; ruminants are VERY sensitive
45
What are the main NSAID options for ruminants?
-flunixin meglumine -meloxicam