Lecture 28: Non-conventional Lymphocytes Flashcards
Recall the characteristics of the various immune cells.
Recall the role of Ikaros.
Ikaros drives the lymphoid transcriptional program and suppresses stem cell or myeloid lineages
Recall the outcomes of T cell lymphocyte commitments.
- Results from TCR recognition of either MHC class II or MHC-I during development in the thymus
- Transcription factor ThPOK leads to commitment to the CD4 lineage
- Transcription factor Runx3 leads to commitment to the CD8 lineage (silences CD4 expression)
NK cells do not strictly develop in the __________. It also do not express ____________________.
Describe ILC.
Recall γδ T cells
Recall the T cell family.
Recall the diagram showing the various developmental pathway of T cells.
Recall how BCRs and TCRs bind to antigen in different ways
Recall NKT cells recognize antigens.
Describe lipid-based antigens
Describe NKT cells characteristics and function.
Recall other types of CD1-restricted T cells and the antigens they detect.
Describe MAIT cells characteristics and antigen recognition.
Recall the differentiation pathways of MAIT and iNKT.
Differ between conventional and non-conventional T cells.
Recall RAG-dependent and RAG-independent lymphocytes.
Recall the groups of ILC.
- ILCs do not have antigen receptors -activated by cytokines -produce cytokines
- Grouped based on phenotypic and functional traits
Recall the parallels between ILC and T helper cell types
Recall how TF and cytokines direct cell fate.
Describe tissue-resident lymphocytes.
