Lecture 28: Non-conventional Lymphocytes

Question 1

Recall the characteristics of the various immune cells.

Answer 1

Question 2

Recall the role of Ikaros.

Answer 2

Ikaros drives the lymphoid transcriptional program and suppresses stem cell or myeloid lineages

Question 3

Recall the outcomes of T cell lymphocyte commitments.

Answer 3

• Results from TCR recognition of either MHC class II or MHC-I during development in the thymus
• Transcription factor ThPOK leads to commitment to the CD4 lineage
• Transcription factor Runx3 leads to commitment to the CD8 lineage (silences CD4 expression)

Question 4

NK cells do not strictly develop in the __________. It also do not express ____________________.

Answer 4

Question 5

Describe ILC.

Answer 5

Question 6

Recall γδ T cells

Answer 6

Question 7

Recall the T cell family.

Answer 7

Question 8

Recall the diagram showing the various developmental pathway of T cells.

Answer 8

Question 9

Recall how BCRs and TCRs bind to antigen in different ways

Answer 9

Question 10

Recall NKT cells recognize antigens.

Answer 10

Question 11

Describe lipid-based antigens

Answer 11

Question 12

Describe NKT cells characteristics and function.

Answer 12

Question 13

Recall other types of CD1-restricted T cells and the antigens they detect.

Answer 13

Question 14

Describe MAIT cells characteristics and antigen recognition.

Answer 14

Question 15

Recall the differentiation pathways of MAIT and iNKT.

Answer 15

Question 16

Differ between conventional and non-conventional T cells.

Answer 16

Question 17

Recall RAG-dependent and RAG-independent lymphocytes.

Answer 17

Question 18

Recall the groups of ILC.

Answer 18

• ILCs do not have antigen receptors -activated by cytokines -produce cytokines
  
  • Grouped based on phenotypic and functional traits

Question 19

Recall the parallels between ILC and T helper cell types

Answer 19

Question 20

Recall how TF and cytokines direct cell fate.

Answer 20

Question 21

Describe tissue-resident lymphocytes.

Answer 21