Lecture 24: Effector Mechanisms of Humoral Immunity Flashcards
Recall the lifecycle of B cells.
Recall B cell activation by TI antigen.
Recall B cell activation by TD antigen.
Recall role of AID enzyme in SMH.
Recall the process of AM and SMH in the germinal centre.
Isotypic switching is regulated by ____________ found upstream of each of the immunoglobulin C-region genes
Isotypic switching is regulated by repetitive DNA ‘switch regions’ found upstream of each of the immunoglobulin C-region genes
Recall how Isotype Switching is initiated.
Recall role of cytokine in IS.
Recall the mechanism of IgD switching.
Recall the mechanism of producing secreted Ig.
Recall the roles of different Ig classes.
Recall the functional activity of different Ig Class
____ and _______ can easily diffuse into tissues.
IgG (principally in blood/extracellular fluids) and IgA (principally in secretions) can easily diffuse into tissues
High-affinity ___ and _____ antibodies are the best at neutralising toxins and blocking the infectivity of viruses and bacteria
High-affinity IgG and IgA antibodies are the best at neutralising toxins and blocking the infectivity of viruses and bacteria
Recall the Fc receptors’ function.
_____________ must bind a pathogen to engage low-affinity FcR
High-affinity FcR can bind monomeric Ig
Recall Antibody-dependent cell-mediated cytotoxicity
Recall the role of IgE-mediated activation
Recall the role of Fc receptors in Ig transport.
