Lecture 27: Immune Regulation Flashcards
Recall the basic mechanism regulating adaptive immunity.
Recall the overview of thymic selection of T cells.
What is the function of AIRE gene?
Recall ignorance of peripheral T cell tolerance.
Antigen presentation is sufficient to elicit an immune response. True or False.
False
Recall the concept of deletion if peripheral T cell tolerance.
Only TCR recognition without co-stimulatory signals may promote apoptotic signalling in the cell.
Describe peripheral deletion by death receptors.
Recall the concept of anergy of peripheral T cell tolerance
Example of biochemical alterations:
- Recruitment of Cbl-b: ubiquitination of TCR components leading to proteasomal degradation
Recall the concept of inhibition in peripheral T cell tolerance.
Describe CTLA-4 and its two function.
Describe PD-1.
A protein on the surface of cells that has a role in regulating the immune system’s response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity.
Recall checkpoint receptor expression in chronic infection.
Recall the concept of checkpoint blockade cancer immunotherapy.
Recall adverse immune events after checkpoint blockade.
Describe Regulatory T cells.
Recall the generation of thymus-derived and peripherally-derived Treg.
Recall the dual role of TGFbeta in Th17 and Treg differentiation.
Treg cells act in _________ and ________________ tissues.
Recall the basic mechanisms of Treg-mediated suppression/
Recall other immunosuppressive mechanisms of Treg cells.
