Lecture 17: Role of Antigen Presenting Cells Flashcards
MHC I molecules present antigens degraded in the _____________.
MHC II molecules present antigens degraded in the _____________.
Recall the process of antigen presentation by MHC I molecules.
Recall the process of antigen presentation by MHC II molecules.
What is an APC?
Differ between professional and non-professional APC.
Recall examples of “professional” APC.
Recall the mechanism of endocytosis in professional APC.
Macrophages require “permission” from CD4+ T cell to __________________ and to ________________________.
B cells use _________________ to ask “permission from _______________ to secrete Ab.
_______ T cells can’t kill target, and ______ T cells can’t give “permission” to macrophages or B cells unless they are activated by _______________.
Recall the importance of dendritic cell.
Dendritic cells provide a “communication link” between _______________ and ___________.
Recall the difference between immature and activated DC.
How does DC detect infections?
Expression of PAMP receptors
Recall the concept of cross-presentation.
As it turns out, certain dendritic cells are able to generate peptide:MHC class I complexes from peptides that were not generated within their own cytosol. Peptides from extracellular sources—such as viruses, bacteria, and phagocytosed dying cells infected with cytosolic pathogens—can be presented on MHC class I molecules on the surface of these dendritic cells by the process of cross-presentation.
Recall an overview of antigen presentation events during an immune response.
Recall the properties of the various APCs.
