Lecture 26- Digestive Physiology And Kidneys Flashcards
Where doe most digestion occur?
In the small intestine
Lacteals
Lymphatic vessels for carrying lipids absorbed in these intestine
Carbohydrate digestion
Begins in the mouth as salivary amylase splits starch into oligosaccharides
In intestine, pancreatic amylase breaks down starch and glycogen into oligosaccharides and disaccharides
Brush border enzymes break oligosaccharides and disaccharides into monosaccharides
Monosaccharides are co transported across apical membrane of absorptive epithelial cells and exit across basolateral membrane by facilitated diffusion
Lactose intolerance
Person has a deficient amount of lactase
Proteins in digestion
Pepsin, secreted by chief cells begins hydrolysis of denatured proteins in stomach
Pancreatic proteases breaks down proteins and proteins fragments into smaller pieces and some individual amino acids in small intestine
Brush border enzymes break oligopeptides and dipeptides into amino acids
Amino acids co transported across apical membrane of absorptive epithelial cell and exit across basolateral membrane by facilitated diffusion
lipid digestion
Small intestine is first site of lipid digestion
Bile salts emulsify lipids from large droplets into smaller droplets
Pancreatic lipases break down emulsified fats into monoglycerides and free fatty acids
Monoglcerides and fatty acids combine with bile salts and lecithin to form micelles
At plasma membrane fatty acids and monoglycerides diffuse into epithelial cells of mucosa
Monoglycerides and fatty acids converted back to triglycerides and combined with lecithin, cholesterol and other lions to form chylomicrons, Exocytosed to interstitial space and taken into lacteals for transport
How are nuclei acids hydrolysed?
By pancreatic nucleuses in pancreatic juice
Vitamins
Organize cofactors that help with metabolism
Most absorbed through small intestine
Water soluble vitamins
Bs and C
Absorbed by diffusion or by passive or active transport
Fat soluble vitamins
A, D,E,K
Carried by micelles of lipids and diffuse into absorptive cells
What percentage of water in chyme does small intestine absorb?
90%
How do kidneys maintain body’s internal environment?
Regulating total blood volume and total solute concentration in blood
Regulating ion concentrations
Ensuring long term pH balance
Excreting metabolic wastes, toxins and drugs
Producing erythropoietin and renin and activating vitamin D
Three layers of suppportive tissue around kidney
Renal fascia- dense fibrous connective tissue, anchors kidney and adrenal gland to surrounding structures
Perirenal fat capsule- surrounds and cushions kidney
Fibrous capsule- prevents surrounding infections from reaching kidney
Blood supply to kidney
Blood enters through on renal artery, flows to cortex until it arrives at afferent arterioles (give rise to microscopic vasculature, key element of kidney function)
Renal nerve plexus
Regulates renal blood flow by adjusting diameter of renal arteriole and influencing urine forming role of nephrons