Lecture 20 Multi System Autoimmune Disease Flashcards
What demographic group does SLE affect the most
Female
Afro-caribbean
Name the classification criteria of SLE (11)
Malar rash (butterfly rash)
Discoid rash (raised, scarring, permanent marks, alopecia)
Photosensitivty
Oral ulcers
Arthritis
Serositis
Renal
Neurological (seizures and psychosis)
Haematological (lows WCC, lymphocytes, haemolytic anaemia)
Immunological (anti ds-DNA, cardiolipin, lupus anticoagulant, low complement)
ANA
What is scleroderma
Scleroderma is caused by the immune system attacking the connective tissue under the skin and around internal organs and blood vessels
Name the clinical features of Scleroderma
Morphoea Sclerodactyly Diffuse cutaneous systemic sclerosis Digital pits on the fingertips Digital ulceration
What are the complications of Scleroderma
Pulmonary hypertension
Pulmonary fibrosis
Renal crisis
Small bowel bacterial overgrowth
What is Sjogren’s Syndrome
Condition that affects parts of the body that produce fluids, like tears and spit (saliva)
What are the symptoms of Sjorgen’s Syndrome
Parotid gland enlargement 1/3 systemic upset Fatigue Fever Myalgia Arthralgia
What are the complications of Sjorgen’s Syndrome
Lyphoma Neuropathy Purpura Interstitial lung disease Renal tubular acidosis
What is autoimmune myositis
Autoimmune condition that leads to muscle weakness (symmetrical, diffuse, proximal)
What are the complications of autoimmune myositis
Cancer, Interstitial lung disease
Name medium vessel vasculitis
Polysrteritis Nodosa
Kawasaki Disease
Name large vessel vasculitis
Gian Cell Arteritis
Takayasu Arteritis
Name small vessel vasculitis
ANCA-Asscociated Vasculitis
Microscopic Polyangiitis
Anti-GBM disease
What is the common age onset of Giant Cell Arthritis
Age at onset >50 years New headache Temporal artery te dermes/reduced pulsation ESR>50 Abnormal temporal biopsy
Name 4 types of ANCA-associated vasculitis
Wegener’s
Microscopic polyangiitis
Eosinophilic granulomatosis with polyangiitis
