Lecture 2- Mechanics of breathing and gas exchange Flashcards
compliance is regulated by … and …
lung elasticity
surface tension
compliance is the inverse of …. and is indicative of the amount of … … needed to ventilate the lung
stiffness
muscle force
if you increase surface tension, then you … pressure
increase
if you decrease radius, you … pressure
increase
surfactant reduces … … by decreasing density of water molecules at air-water interface
surface tension
surfactant is an …. …. + protein molecule that forms a monolayer between air and water
amphipathic phospholipid
T/F surfactant has a greater effect in larger alveoli than small
false. greater effect on small
surfactant does not create additional surface tension and will … compliance
increase
production of surfactant is regulated by … receptors in type 2 cells; so … breathing increases surfactant production
stretch
deep
which is more important in increasing lung compliance?
overcoming surface tension
lung elasticity
overcoming surface tension
what is the 2nd leading cause of death in premature infants?
ARDs
surfactant deficiency leads to…
respiratory distress
whats is the therapy for ARDs?
mechanical ventilation and artificial surfactant
if resistance is increased than you breathe more …. to increase change in pressure.
You breathe more … because airflow during expiration is limited
deeply
slowly
if compliance is decreased then you breathe more … to compensate for reduced change in volume and change in pressure.
You breathe more …. to minimize muscle effort
rapidly
shallowly
… causes increased airway resistance because of inappropriate contraction of smooth muscle
asthma
how can asthma be treated
glucocorticoud therapy and/or bronchodilators
… increases airway resistance and is often associated with smoking
COPD
…. is a disease where the alveolar tissues are damaged or destroyed perhaps due to overproduction of proteolytic enzymes
emphysema
emphysema results in airway …, lack of … and difficulty in …
collapse
recoil
expiring
… is when mucus or inflammation impairs airflow and this leads to increased … and … breathing
chronic bronchitis
resistance
deeper
inspiratory reserve volume is …. x the tidal volume
6x
expiratory reserve volume is …. x the tidal volume
3x
… volume is the amount of air that stays in the lungs after maximum expiration
residual
clinically relevant measures of lung volumes
vital capacity
forced expiratory volume in 1 second (FEV1)
in a healthy lung, FEV1 is usually … % of vital capacity
80%