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Block 1: Neuroscience > Lecture 2 > Flashcards

Lecture 2 Flashcards

1
Q

Can cross Plasma Membrane Readily?

A

Only small and lipophilic molecules

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2
Q

Ions and larger polar molecules can cross membrane with help from?

A

Transporters and ion channels

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3
Q

Ion Channels?

A

1) Leak
2) Stretch-Activated
3) Ligand-Gated
4) Voltage-Gated

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4
Q

Leak?

A

(1st)
Constitutively active channels

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5
Q

Stretch-Activated?

A

(2nd) When plasma membrane is stretched, channel is activated

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6
Q

Ligand-Gated?

A

(3rd) A molecule (ex. neurotransmitter) binds to the protein to activate a channel

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7
Q

Voltage-Gated?

A

(4th) Channel activates following a change in membrane potential

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8
Q

Transient changes in membrane potential caused by orchestrated opening and closing of ion channels?

A

Action Potential

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9
Q

From - to +?

A

Depolarization

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10
Q

From + to -?

A

Repolarization

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11
Q

Membrane Potential?

A

(Em) Voltage difference across lipid bilayer

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12
Q

Membrane Potential is created by?

A

Varying concentrations of ions on either side of the plasma membrane

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13
Q

Equilibrium (Nernst) Potential?

A

(Eeq)
Reflects a balance (at equilibrium) between the chemical and electrical gradients for a single permeable ion

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14
Q

Equilibrium (Nernst) Potential Equation?

A
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15
Q

Z is the?

A

Ion Charge

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16
Q

Direction of an Ion moves can be determined by knowing?

A

Equilibrium and Membrane Potential for that Ion

17
Q

Membrane Potential will always want to go towards?

A

Equilibrium

18
Q

Cation(+)
Em<Eeq = ?

A

Moves IN

19
Q

Cation(+)
Em>Eeq = ?

A

Moves OUT

20
Q

Anion(-)
Em<Eeq = ?

A

Moves OUT

21
Q

Anion(-)
Em>Eeq = ?

A

Moves IN

22
Q

Goldman Equation describes?

A

Resting Membrane Potential, accounting for the relative permeabilities, and concentration gradients of the 3 primary permeable ions

23
Q

Goldman Equation?

A
24
Q

As external [K+] increases?

A

Em becomes less negative (depolarization)

25
Q

As external [K+] decreases?

A

Em becomes more negative (hyper polarization)

Block 1: Neuroscience (15 decks)

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