Lecture 19 Nervous Tissue I Flashcards
The neural plate is composed of what type of epithelium?
Simple columnar epithelium
In the neural plate, cell shape is maintained by:
Microtubules
In the neural folds, columnar cell shape changes to:
wedge cell shape
In the neural folds, the shape change is due to:
actin filaments
The wedge shape of cells in the neural fold causes:
Flattened neural plate to bend
Neuroepithelial cells from embryonic neuroectoderm give rise to _____.
neuroblasts
Neuroblasts give rise to _____ of the central nervous system (brain and spinal cord).
Neurons
______ _______ cells are derived from the neuroectoderm and give rise to neurons and neuroglial cells of the peripheral nervous system
Neural Crest Cells
Pseudostratified epithelium
Ventricular zone
Intermediate zone
Ventricular zone
made up of ventricular cells
Intermediate zone
Area of destruction of excess neurons via apoptosis
Cortical plate (mantle layer)
Postmitotic neurons
Future gray matter (cell bodies, dendrites, and unmyelinated axons)
Marginal Layer
Axons
Future white matter (myelinated axons
Characteristics of Nerve Tissue
Irritability
Conductibility
Irritability
Specialized to receive stimuli
Conductibility
Specialized to transmit impulses
Cellular components of Nerve Tissue
Neurons
Neuroglial cells
Neurons
Conduct impulses
Fundamental structural and functional unit of the nervous system
Neuroglial Cells
Nonconductive cells that support and protect the neurons
Parts of the neuron
Cell body (soma)
Dendrites
Axon
Characteristics of the cell body of a neuron
Contains nucleus
Nissl bodies
Extensive RER and elaborate Golgi structures
Abundant mitochondria
Abundant microtubules and intermediate filaments
Lipofucsin granules formed from lysosomes & accumulate with age of neuron
Ligand-gated channels and local potentials
Characteristics of Dendrites
Conduct impulses (local) toward cell body
Contain Nissl substance, mitochondria, & other cytoplasmic components (except Golgi)
May be stubbed w/ dendritic spines
Tend to taper distally and may branch
Ligand-gated channels and local potentials
Characteristics of the Axon Hillock
Site for origin of axon
Devoid of Nissl substance
Associated with AP generation
Characteristics of the Axon
Voltage-gated cation channels & APs Contain mitochondria and microtubules Lack RER, ribosomes, and Golgi Constant diameter its entire length Terminates in branching telodendrites Telodendrites contain synaptic vesicles & related proteins Telodendrites form presynaptic membranes May be enclosed within myelin sheath
Classification of neurons according to function:
Sensory (afferent) neurons
Motor (efferent) neurons
Interneurons
Sensory (afferent) neurons
Transmit sensory impulses from sensory receptors to CNS
Motor (efferent) neurons
Transmit impulses from CNS to muscle of gland
Somatic - skeletal muscles
Autonomic - glands, cardiac, and smooth muscle (parasym and sym)
Interneurons
Transmit impulses within CNS and between sensory and motor neurons
Classification of neurons according to number of processes
Multipolar neurons
Bipolar
Pseudounipolar
Multipolar neurons
Most common morphological type
Have single axon and multiple dendrites
Bipolar neurons
Have to processes, one at end end of the spindle-shaped neuron
Found in association of special senses such as olfactory and visual
Pseudounipolar
Single process from the cell body that bifurcates into central & peripheral processes
Found in ganglia alongside spinal cord (dorsal root ganglia)
Classification of neuron according to length of axon
Golgi I
Golgi II
Golgi I
neurons with long axon which leave the grey matter of which they are a part
Golgi II
Neurons with short axons which ramify through the gray matter
Nerve
Bundles of axons (fibers) in the PNS
Tract
Bundle of axons (fibers) in the CNS
Ganglion
Aggregation of cell bodies and dendrites in the PNS
Nucleus
Aggregation of cell bodies and dendrites in the CNS
Epineurium
Thick fibrous coat
Covers entire nerve
Supplied by blood and lymphatic vessels
Type I collagen and fibroblasts
Perineurium
Dense CT
Covers bundles of axons (fascicles) within nerve
Epithelial-like fibroblast on inner surface joined by tight junctions (zonula occludens)
Blood nerve barrier
Endoneurium
Thin layer of reticular CT
Surrounds individual fibers and Schwann cells
Type III collagen
Membrane specializations
Receptors
Ion channels:
- ligand gated on dendrites & cell bodies
- potassium channels, v-gated Na channels, and v-gated Ca channels on axon
Membrane specializations at the presynaptic membrane
Synaptic vesicles Vesicular docking proteins & synapsin filaments Dense bodies Mitochondria Voltage-gated calcium channels
Membrane specializations at the postsynaptic membrane
Receptors
Ligand-gated ion channels
In what direction does anterograde transport travel?
Cell body toward distal end of axon
Anterograde transport utilizes ______.
Kinesin
Slow Anterograde Transport
Only used in anterograde direction
Two systems:
- SCa (slow component a): preassembled microtubules and neurofilaments
- SCb (slow component b): enzymes, actin, clathrin
Intermediate Anterograde Transport
50-100 mm per day
Mitochondria & other membrane-bound organelles
Fast Anterograde Transport
Utilizes microtubule motors
400 mm per day
Synaptic vesicles & neurotransmitters
In what direction does retrograde transport travel?
Axon toward cell body
Retrograde transport utilizes ____ ______.
Cytoplasmic dynein
Retrograde transport carries:
endocytosed materials & recycled proteins
Rate of transport for retrograde transport
100-300 mm/day