Lecture 19 - CHF

Question 1

Left sided CHF occurs when the heart can’t keep up with the venous return from the _____. This of course leads to edema in the _____ (Rales on auscultation) and histology will show hemosiderin-laden alveolar _______ (aka heart failure cells) and cardiomyocytes with characteristic “_______” nuclei.

Answer 1

Lungs

Lungs

Macrophages

“Boxcar” nuclei

Question 2

Right-sided heart failure typically develops from left-sided heart failure and resultant increases in _______ BP (Cor Pulmonale).

Answer 2

Pulmonary BP

Question 3

Restricted cardiomyopathy occurs as a result of increased _______ of the heart muscle.

Answer 3

Stiffness

Question 4

Hypertrophic cardiomyopathy is ____% genetic. The heart develops _____ ventricular hypertrophy WITHOUT dilation, and the hypertrophy is asymmetric (often in the subaortic region of the septum.)

Answer 4

100%

Left ventricular hypertrophy

Question 5

Histology of Hypertrophic cardiomyopathy shows a characteristic ______ (order or disarray?) of cardiomyocytes.

Answer 5

Disarray

Question 6

The 2 key histology findings to identify Myocarditis are ______ inflammatory infiltrate and focal _____ of myocytes adjacent to the inflammatory cells.

Answer 6

Interstitial (between the myocytes)

Necrosis