Lecture 19 - Blood Gas Transport

Question 1

State Dalton’s Law

Answer 1

The pressure exerted by a mixture of gases is the sum of the pressures exerted independently by each gas in the mixture

Question 2

State Henry’s Law

Answer 2

The amount of a gas that dissolves in water is determined by its Solubility in Water and its Partial Pressure in Air

Question 3

When pH decreases and pCO2 increases, what shift occurs in the Oxygen Dissociation Curve and what is this shift called?

Answer 3

It shifts to the right (the Bohr Shift)

Question 4

What is the other form of haemoglobin caused by it binding with a gas other than O2 (and what is this gas?)

Answer 4

Carboxyhaemoglobin (carbon monoxide)

Question 5

What is the name of haemoglobin when its Fe2+ has been oxidised to Fe3+?

Answer 5

Methaemoglobin

Question 6

What is structurally different about Foetal Haemoglobin?

Answer 6

2 alpha and 2 GAMMA units (instead of 2 alpha and 2 beta)

Question 7

Name the three forms in which CO2 is transported in the blood (and their approx %s)

Answer 7

70% = bicarbonate ions (HCO3-)
23% = carbaminohaemoglobin
7% = dissolved in plasma

Question 8

What is the Haldane effect?

Answer 8

A change in the affinity of Hb for H+, depending on its oxygenation status