Lecture 18: Autism Spectrum Disorder Flashcards

1
Q

Theory of mind - (2)

A

The ability to represent mental states including the repsentation of:
1. One’s own mental state
2. Other’s mental states

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2
Q

Mental states include: (6)

A
  1. Thoughts
  2. Beliefs
  3. Emotions
  4. Motivations
  5. Intentions
  6. Desires
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3
Q

Deficits in ToM are common and perhaps universal among people with ASD

Some tests reveal differences between people with ASD and people without. What are some key differences (7)

A
  1. Mental vs physical
  2. Functions of the brain
  3. Appearance vs reality
  4. First-order belief tasks
  5. Second-order belief tasks
  6. Inferences from gaze-direction
  7. Seeing leads to knowing
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4
Q

Mental vs physical representation deficits in ASD Example

A

One person is holding a dog and another person is thinking about a dog. Who can pet the dog?

Children with ASD have difficulty answering.

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5
Q

Functions of the brain deficit example

A

Children at 4 with ASD have difficulty naming parts of the brain

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6
Q

Appearance vs reality representation example

A

Children at 4 with ASD mistake appearance for reality more than children without ASD eg. A candle shaped like an apple

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7
Q

First-order belief tasks difficulty example

A

Children at 4 with ASD have difficulty attributing belief states to others eg. Mommy believes I brushed my teeth

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8
Q

Second-order belief tasks deficit example

A

Children at 6 with aSD have difficulty attributing beliefs about beliefs eg. Mommy believes that Daddy believes I brushed my teeth

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9
Q

Inferences from gaze direction deficit example

A

Children at 4 with aSD have difficulty inferring what someone wants/interested in from the direction where they’re looking

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10
Q

Seeing leads to knowing deficit example

A

Children at 3 with ASD have difficulty with the principle that seeing leads to knowing eg. One person touches a box while the other looks into it. Who knows what’s in the box.

Children with ASD have difficulty answering

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11
Q

Other tasks children with ASD have difficulty with other than the main 6 (2)

A
  1. Deception
  2. Detecting deception/irony/jokes
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12
Q

Who is more likely to have ASD between males/females

A

Males

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13
Q

When are symptoms first observed for people with ASD

A

Early depending on severity but usually 2 years

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14
Q

Some children with ASD undergo a period of social regression which means?

A

The loss of developed social capacities

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15
Q

ASD is classified as a __________ disorder

A

Neurodevelopmental disorder

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16
Q

Because ASD is classified as a neurodevelopmental disorder it indicates that it involves:?

A

Atypical brain development during the first years of life

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17
Q

Is ASD a neurodegenerative disorder?

Yes/No - What does this mean?

A

No - learning and skill building can occur!

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18
Q

There is a wide range in the degree of _____ and _______ among people with ASD

A

Distress and impairment

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19
Q

Level 1 of Distress and impairment levels in people with ASD - without support deficits in social communication are noticeable (3)

A
  1. Difficulty with back/forth conversation
  2. Mild difficulty switching between activities
  3. Interests are somewhat limited
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20
Q

Level 2 of Distress and impairment levels in people with ASD - deficits in social communication are evidence even with support in place e

A
  1. Most communications highly fixated on one topic
  2. Moderate difficulty switching between activities
  3. Interests are limited to a narrow range
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21
Q

Level 3 of Distress and impairment levels in people with ASD - Severe deficits in social communication (3)

A
  1. Difficulty initiating any social interaction
  2. Severe distress when switching between activities
  3. Severely limited interests interfere with functioning in all domains
22
Q

Associated features of ASD (10)

A
  1. High rates of comorbidities
  2. Language impairment
  3. Intellectual disability
  4. Motor control problems
  5. Catalonia
  6. Self-aggression
  7. Inattention/hyperactivity/impulsivity
  8. Sleep disorders
  9. Seizures
  10. Anxiety and depression
23
Q

Catalonia

A

Non-responsiveness to people/environment, mutism, unusual body position, and/or repetitive non-goal directed movement

24
Q

Why might people with ASD have a seizure disorder?

A

Underlying cause of cerebral dysgenesis (abnormal brain development)

25
Risk factors for developing ASD (6)
1. Advanced parental age 2. Low birth weight 3. Prenatal exposure to Dpakote (valproate) - used to treat seizures and BPD, or thalidomide - used to treat cancer 4. Epilepsy 5. Suboptimal prenatal environment 6. Genetic factors
26
Suboptimal prenatal environment examples (4)
1. Advances maternal age 2. Maternal diabetes 3. Placental insufficiency 4. Maternal infections eg. Rubella
27
Heritability
The proportion of phenotypic variance in a population that is attributable to genetic variance
28
The remainder of phenotypic variance in a population not attributable to genetic variance is attributable to _________ ________ or ________
Environmental variance/chance
29
Heritability is a measure of (2)
1. Phenotypic differences (doesn’t tell us about how much a trait value is attributable to genes vs environment) 2. Population differences (tells us nothing about individual organisms
30
Genetic contribution to ASD is polygenic meaning:
Many genes contribute a small risk to the development of ASD
31
Biological factors associated with ASD (9)
1. Macrocephaly 2. Large brain size 3. Atypical structure under activation of amygdala 4. Atypical structure and under activation of frontal cortex 5. Atypical structure of cerebellum 6. Atypical structure and under activation of fish form gyrus 7. Under activation of mirror neurons in motor cortex 8. Elevated serotonin 9. Higher levels fo autoantibodies
32
Macrocephaly
Large head size
33
Amygdala mediates ____; causes of acquired autism follow amygdalotomy
Emotion
34
Frontal cortex mediates (2)
1. Executive functioning 2. Theory of mind
35
Cerebellum mediates
Movement
36
Fusiform gyrus mediates
Face recognition
37
Elevated serotonin can affect/contribute to
1. Cell migration 2. Differentiation 3. Synaptogenesis during brain development 4. Cerebral dysgensis - abnormal brain development
38
Autoantibodies
Antibodies that attack host cells
39
Controversies related to ASD
1. ASD diagnosis rates are increasing but is that due to actual increase in cases or increases in detection? 2. Vaccine induced ASD eg. Measles-mumps-rubella vaccine 3. Mercury in vaccines
40
Treatment of ASD
1. Applied behavioral analysis 2. Relationship-based treatments 3. Parent training 4. Treatment of comorbidities 5. Pharmacotherapy
41
Applied behavioral analysis uses _____ and _______ __________ to promote socially normative behaviors and behavioral flexibility. This can be done at home/school
Positive and negative reinforcement
42
In addition to positive and negative reinforces common principles of applied behavioral analysis include: (5)
1. Shaping 2. Fading 3. Extinction 4. Punishment 5. Differential reinforcement
43
Shaping
Rewarding approximations or components of a desired behavior until target behavior is exhibited
44
Fading
Reducing prompts to increase independence
45
Extinction
Removal of a reinforcement that maintains a problematic behavior
46
Punishment
Subtracting something gratifying or adding something aversive
47
Differential reinforcement
Rewarding the absence of a behavior
48
Relationship-based treatments - Uses childhood developmental science to formulate interventions designed to improve developmental progression like (6)
1. Joint attention 2. Imitation 3. Cooperation 4. Theory of mind 5. Verbal communication 6. Non-verbal communication
49
Parent training includes (2)
1. Psychoeducation 2. Coaching
50
Pharmacotherapy for ASD is actually for ______ disorders eg. _________, _________, and __________
Comorbid Eg. Antidepressants, Antipsychotics, Stimulants (for comorbid ADHD)
51
Neurodiversity movement - Groups of people with ASD, parents of people with ASD, and some medically and mental health professionals who advocate for (3)
1. A reconceptualization of ASD 2. Destigmatization and demarginalzaition of people with ASD 3. Efforts to reduce unfair discrimination of people with ASD
52
Reconceptualization of ASD - from medical diagnosis/psychiatric disorder into ?
Atypical but not pathological developmental outcome